Detailed information of TA system TA197057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1394872..1395431
• Replicon: chromosome
• Accession: NZ_CP071857
• Organism: Vibrio sp. SCSIO 43145

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7H5CQX1
• Locus tag: J4N38_RS06490
• Protein ID: WP_025796573.1
• Coordinates: 1394872..1395150 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J4N38_RS06495
• Protein ID: WP_239871581.1
• Coordinates: 1395147..1395431 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4N38_RS06460 (J4N38_06425)	1390327..1390782	+	456	Protein_1242	GNAT family N-acetyltransferase	-
J4N38_RS06465 (J4N38_06430)	1391454..1392395	+	942	WP_193275176.1	DUF4263 domain-containing protein	-
J4N38_RS06470 (J4N38_06435)	1392420..1392512	+	93	WP_193275177.1	DUF3265 domain-containing protein	-
J4N38_RS06475 (J4N38_06440)	1392570..1393256	+	687	WP_252036381.1	hypothetical protein	-
J4N38_RS06480 (J4N38_06445)	1393526..1394032	-	507	WP_252036382.1	HNH endonuclease signature motif containing protein	-
J4N38_RS06485 (J4N38_06450)	1394462..1394698	+	237	WP_252036383.1	hypothetical protein	-
J4N38_RS06490 (J4N38_06455)	1394872..1395150	-	279	WP_025796573.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
J4N38_RS06495 (J4N38_06460)	1395147..1395431	-	285	WP_239871581.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J4N38_RS06500 (J4N38_06465)	1395644..1395961	+	318	WP_252036384.1	hypothetical protein	-
J4N38_RS06505 (J4N38_06470)	1396241..1396462	+	222	WP_004400149.1	VF530 family protein	-
J4N38_RS06510 (J4N38_06475)	1396909..1397055	+	147	WP_252036385.1	hypothetical protein	-
J4N38_RS06515 (J4N38_06480)	1397065..1397394	+	330	WP_252036386.1	hypothetical protein	-
J4N38_RS06520 (J4N38_06485)	1397561..1398337	+	777	WP_252040095.1	deaminase	-
J4N38_RS06525 (J4N38_06490)	1398827..1398985	+	159	WP_252036388.1	hypothetical protein	-
J4N38_RS06530 (J4N38_06495)	1398992..1399531	+	540	WP_252036389.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1344026..1496374	152348
	-	inside	Integron	-	-	1343019..1495238	152219

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10916.54 Da
• Isoelectric Point: 4.3697

>T197057 WP_025796573.1 NZ_CP071857:c1395150-1394872 [Vibrio sp. SCSIO 43145]
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T197057 NZ_CP095538:1618666-1618920 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10985.32 Da
• Isoelectric Point: 8.0498

>AT197057 WP_239871581.1 NZ_CP071857:c1395431-1395147 [Vibrio sp. SCSIO 43145]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQINLAFEKFDSGKATFIDHESAKSR
MDERKAKIRNRGKL

Nucleotide

• Length: 285 bp

>AT197057 NZ_CP095538:1618418-1618669 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A7H5CQX1