Detailed information of TA system TA197056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1385112..1385657
• Replicon: chromosome
• Accession: NZ_CP071857
• Organism: Vibrio sp. SCSIO 43145

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A151KUE6
• Locus tag: J4N38_RS06425
• Protein ID: WP_038939651.1
• Coordinates: 1385112..1385408 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: J4N38_RS06430
• Protein ID: WP_239866745.1
• Coordinates: 1385415..1385657 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4N38_RS06380 (J4N38_06355)	1380223..1380573	+	351	WP_252036372.1	hypothetical protein	-
J4N38_RS06385 (J4N38_06360)	1381188..1381497	+	310	Protein_1227	DUF4144 family protein	-
J4N38_RS06390 (J4N38_06365)	1381640..1382137	+	498	WP_170966842.1	hypothetical protein	-
J4N38_RS06395 (J4N38_06370)	1382275..1382646	+	372	WP_252036373.1	RidA family protein	-
J4N38_RS06400 (J4N38_06375)	1382798..1383187	+	390	WP_252036374.1	hypothetical protein	-
J4N38_RS06405 (J4N38_06380)	1383331..1383786	-	456	WP_252036375.1	hypothetical protein	-
J4N38_RS06410	1383869..1384051	+	183	WP_252036376.1	hypothetical protein	-
J4N38_RS06415 (J4N38_06385)	1384393..1384533	+	141	WP_252036377.1	hypothetical protein	-
J4N38_RS06420 (J4N38_06390)	1384593..1384940	+	348	WP_239866754.1	hypothetical protein	-
J4N38_RS06425 (J4N38_06395)	1385112..1385408	-	297	WP_038939651.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J4N38_RS06430 (J4N38_06400)	1385415..1385657	-	243	WP_239866745.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J4N38_RS06435 (J4N38_06405)	1385911..1386648	+	738	WP_239876928.1	SDR family oxidoreductase	-
J4N38_RS06440	1386626..1386763	+	138	WP_239876929.1	DUF3265 domain-containing protein	-
J4N38_RS06445 (J4N38_06410)	1388072..1388320	+	249	WP_252036378.1	hypothetical protein	-
J4N38_RS06450 (J4N38_06415)	1388549..1388785	+	237	WP_252036379.1	hypothetical protein	-
J4N38_RS06455 (J4N38_06420)	1389176..1389838	+	663	WP_252036380.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1344026..1496374	152348
	-	inside	Integron	-	-	1343019..1495238	152219

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11278.93 Da
• Isoelectric Point: 9.6269

>T197056 WP_038939651.1 NZ_CP071857:c1385408-1385112 [Vibrio sp. SCSIO 43145]
MQKNKYKLSKLAQTHLQKIKNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T197056 NZ_CP095538:1618418-1618669 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9030.23 Da
• Isoelectric Point: 4.7914

>AT197056 WP_239866745.1 NZ_CP071857:c1385657-1385415 [Vibrio sp. SCSIO 43145]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLVQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT197056 NZ_CP095538:1618666-1618920 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A151KUE6