Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1887564..1888111 | Replicon | chromosome |
| Accession | NZ_CP071855 | ||
| Organism | Vibrio sp. SCSIO 43153 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | J4N37_RS08935 | Protein ID | WP_222327475.1 |
| Coordinates | 1887564..1887866 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | J4N37_RS08940 | Protein ID | WP_005448240.1 |
| Coordinates | 1887854..1888111 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4N37_RS08880 (J4N37_08790) | 1882714..1882824 | - | 111 | WP_252042132.1 | DUF3265 domain-containing protein | - |
| J4N37_RS08885 (J4N37_08795) | 1882843..1883304 | - | 462 | WP_017817956.1 | GNAT family N-acetyltransferase | - |
| J4N37_RS08890 (J4N37_08800) | 1883469..1883633 | - | 165 | WP_162836306.1 | hypothetical protein | - |
| J4N37_RS08895 (J4N37_08805) | 1883635..1884057 | - | 423 | WP_025527504.1 | hypothetical protein | - |
| J4N37_RS08900 (J4N37_08810) | 1884219..1884311 | - | 93 | WP_005445734.1 | DUF3265 domain-containing protein | - |
| J4N37_RS08905 (J4N37_08815) | 1884326..1885222 | - | 897 | WP_252040632.1 | hypothetical protein | - |
| J4N37_RS08910 (J4N37_08820) | 1885251..1885343 | - | 93 | WP_193788677.1 | DUF3265 domain-containing protein | - |
| J4N37_RS08915 (J4N37_08825) | 1885369..1886073 | - | 705 | WP_046874576.1 | HNH endonuclease | - |
| J4N37_RS08920 (J4N37_08830) | 1886221..1886649 | - | 429 | WP_045388715.1 | hypothetical protein | - |
| J4N37_RS08925 (J4N37_08835) | 1886769..1887395 | - | 627 | WP_025527508.1 | LysE family translocator | - |
| J4N37_RS08930 | 1887490..1887567 | - | 78 | Protein_1722 | DUF3265 domain-containing protein | - |
| J4N37_RS08935 (J4N37_08840) | 1887564..1887866 | - | 303 | WP_222327475.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J4N37_RS08940 (J4N37_08845) | 1887854..1888111 | - | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J4N37_RS08945 (J4N37_08850) | 1888300..1888848 | - | 549 | WP_252040634.1 | hypothetical protein | - |
| J4N37_RS08950 (J4N37_08855) | 1888875..1888964 | - | 90 | WP_072828858.1 | DUF3265 domain-containing protein | - |
| J4N37_RS08955 (J4N37_08860) | 1889514..1890161 | - | 648 | WP_252040635.1 | hypothetical protein | - |
| J4N37_RS08960 (J4N37_08865) | 1890327..1890854 | - | 528 | WP_252040637.1 | GIY-YIG nuclease family protein | - |
| J4N37_RS08965 (J4N37_08870) | 1891030..1891500 | - | 471 | WP_252040639.1 | metal ABC transporter ATPase | - |
| J4N37_RS08970 (J4N37_08875) | 1891512..1891604 | - | 93 | WP_080277174.1 | DUF3265 domain-containing protein | - |
| J4N37_RS08975 (J4N37_08880) | 1891619..1892437 | - | 819 | WP_252040641.1 | DUF2971 domain-containing protein | - |
| J4N37_RS08980 (J4N37_08885) | 1892466..1892558 | - | 93 | WP_079853922.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1809131..1926795 | 117664 | |
| - | inside | Integron | - | - | 1810978..1926795 | 115817 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11708.65 Da Isoelectric Point: 5.8692
>T197055 WP_222327475.1 NZ_CP071855:c1887866-1887564 [Vibrio sp. SCSIO 43153]
MAEIIWTEPALSDLNDIAEYIAIENIVAAKQLVQTIFSRVERLQIFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERNLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIAIENIVAAKQLVQTIFSRVERLQIFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERNLRKFLLSKQ
Download Length: 303 bp
>T197055 NZ_CP095538:642671-643078 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT197055 WP_005448240.1 NZ_CP071855:c1888111-1887854 [Vibrio sp. SCSIO 43153]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT197055 NZ_CP095538:642424-642690 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|