Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2197985..2198544 Replicon chromosome
Accession NZ_CP071852
Organism Vibrio sp. SCSIO 43155

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J4N44_RS10570 Protein ID WP_252044435.1
Coordinates 2198266..2198544 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4N44_RS10565 Protein ID WP_252044434.1
Coordinates 2197985..2198269 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N44_RS10490 (J4N44_10435) 2193255..2193344 - 90 WP_110178323.1 DUF3265 domain-containing protein -
J4N44_RS10495 (J4N44_10440) 2193373..2193717 - 345 WP_252044429.1 antibiotic biosynthesis monooxygenase -
J4N44_RS10500 2193896..2193958 - 63 Protein_2042 DUF3265 domain-containing protein -
J4N44_RS10505 (J4N44_10445) 2193961..2194275 - 315 WP_171343458.1 hypothetical protein -
J4N44_RS10510 (J4N44_10450) 2194299..2194391 - 93 WP_193222931.1 DUF3265 domain-containing protein -
J4N44_RS10515 (J4N44_10455) 2194406..2194879 - 474 WP_152163195.1 hypothetical protein -
J4N44_RS10520 (J4N44_10460) 2194908..2195000 - 93 WP_083135879.1 DUF3265 domain-containing protein -
J4N44_RS10525 (J4N44_10465) 2195024..2195560 - 537 WP_025543342.1 HEPN domain-containing protein -
J4N44_RS10530 (J4N44_10470) 2195589..2195720 - 132 WP_252044430.1 DUF3265 domain-containing protein -
J4N44_RS10535 2195807..2196109 + 303 WP_252044432.1 hypothetical protein -
J4N44_RS10540 (J4N44_10475) 2196209..2196298 - 90 WP_252045110.1 DUF3265 domain-containing protein -
J4N44_RS10545 (J4N44_10480) 2196316..2196669 - 354 Protein_2051 DUF4345 domain-containing protein -
J4N44_RS10550 (J4N44_10485) 2196745..2196855 - 111 Protein_2052 DUF3265 domain-containing protein -
J4N44_RS10555 (J4N44_10490) 2197269..2197397 - 129 WP_077200607.1 DUF3265 domain-containing protein -
J4N44_RS10560 (J4N44_10495) 2197817..2197908 - 92 Protein_2054 DUF3265 domain-containing protein -
J4N44_RS10565 (J4N44_10500) 2197985..2198269 + 285 WP_252044434.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J4N44_RS10570 (J4N44_10505) 2198266..2198544 + 279 WP_252044435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N44_RS10575 (J4N44_10510) 2198573..2198665 - 93 WP_080553424.1 DUF3265 domain-containing protein -
J4N44_RS10580 (J4N44_10515) 2198680..2199603 - 924 WP_252044436.1 chromosome partitioning protein ParA -
J4N44_RS10585 (J4N44_10520) 2199630..2199722 - 93 WP_140106245.1 DUF3265 domain-containing protein -
J4N44_RS10590 (J4N44_10525) 2199737..2200384 - 648 WP_252044384.1 hypothetical protein -
J4N44_RS10595 (J4N44_10530) 2200432..2200560 - 129 WP_099098883.1 DUF3265 domain-containing protein -
J4N44_RS10600 2201033..2201095 - 63 Protein_2062 DUF3265 domain-containing protein -
J4N44_RS10605 (J4N44_10535) 2201098..2201412 - 315 WP_171343458.1 hypothetical protein -
J4N44_RS10610 (J4N44_10540) 2201436..2201528 - 93 WP_252044437.1 DUF3265 domain-containing protein -
J4N44_RS10615 (J4N44_10545) 2201556..2201972 - 417 WP_230856658.1 hypothetical protein -
J4N44_RS10620 (J4N44_10550) 2202191..2203153 + 963 WP_074050631.1 integron integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2145018..2203153 58135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10904.62 Da        Isoelectric Point: 4.4290

>T197054 WP_252044435.1 NZ_CP071852:2198266-2198544 [Vibrio sp. SCSIO 43155]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTN

Download         Length: 279 bp

>T197054 NZ_CP095538:c480947-480570 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11026.37 Da        Isoelectric Point: 8.0517

>AT197054 WP_252044434.1 NZ_CP071852:2197985-2198269 [Vibrio sp. SCSIO 43155]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNLGKQ

Download         Length: 285 bp

>AT197054 NZ_CP095538:c481404-481024 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References