Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2162861..2163420 Replicon chromosome
Accession NZ_CP071852
Organism Vibrio sp. SCSIO 43155

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J4N44_RS10165 Protein ID WP_069523642.1
Coordinates 2163142..2163420 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4N44_RS10160 Protein ID WP_252044398.1
Coordinates 2162861..2163145 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N44_RS10100 (J4N44_10065) 2157939..2158289 - 351 WP_010448889.1 nucleotide pyrophosphohydrolase -
J4N44_RS10105 (J4N44_10070) 2158339..2158467 - 129 WP_099098883.1 DUF3265 domain-containing protein -
J4N44_RS10110 (J4N44_10075) 2158886..2158978 - 93 WP_252044396.1 DUF3265 domain-containing protein -
J4N44_RS10115 (J4N44_10080) 2159068..2159325 - 258 WP_240701386.1 GrpB family protein -
J4N44_RS10120 (J4N44_10085) 2159364..2159456 - 93 WP_006074995.1 DUF3265 domain-containing protein -
J4N44_RS10125 (J4N44_10090) 2159477..2160004 - 528 WP_005445729.1 CbrC family protein -
J4N44_RS10130 (J4N44_10095) 2160033..2160125 - 93 WP_131170466.1 DUF3265 domain-containing protein -
J4N44_RS10135 (J4N44_10100) 2160236..2161396 + 1161 WP_252044397.1 PAAR domain-containing protein -
J4N44_RS10140 (J4N44_10105) 2161393..2161902 + 510 WP_017191342.1 hypothetical protein -
J4N44_RS10145 (J4N44_10110) 2161972..2162061 - 90 WP_080607142.1 DUF3265 domain-containing protein -
J4N44_RS10150 (J4N44_10115) 2162079..2162624 - 546 WP_017634131.1 N-acetyltransferase -
J4N44_RS10155 (J4N44_10120) 2162664..2162784 - 121 Protein_1973 DUF3265 domain-containing protein -
J4N44_RS10160 (J4N44_10125) 2162861..2163145 + 285 WP_252044398.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J4N44_RS10165 (J4N44_10130) 2163142..2163420 + 279 WP_069523642.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
J4N44_RS10170 (J4N44_10135) 2163449..2163577 - 129 WP_071652159.1 DUF3265 domain-containing protein -
J4N44_RS10175 (J4N44_10140) 2163996..2164088 - 93 WP_010644636.1 DUF3265 domain-containing protein -
J4N44_RS10180 (J4N44_10145) 2164103..2164837 - 735 WP_252044399.1 hypothetical protein -
J4N44_RS10185 (J4N44_10150) 2164876..2164965 - 90 WP_252045109.1 DUF3265 domain-containing protein -
J4N44_RS10190 (J4N44_10155) 2164983..2165888 - 906 WP_181146209.1 hypothetical protein -
J4N44_RS10195 (J4N44_10160) 2165931..2166023 - 93 WP_080252015.1 DUF3265 domain-containing protein -
J4N44_RS10200 (J4N44_10165) 2166038..2166817 - 780 WP_252044400.1 hypothetical protein -
J4N44_RS10205 (J4N44_10170) 2166938..2167459 - 522 WP_252044401.1 GNAT family N-acetyltransferase -
J4N44_RS10210 2167544..2167606 - 63 Protein_1984 DUF3265 domain-containing protein -
J4N44_RS10215 (J4N44_10175) 2167609..2167923 - 315 WP_171343458.1 hypothetical protein -
J4N44_RS10220 (J4N44_10180) 2168064..2168345 - 282 WP_252044402.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2145018..2203153 58135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-44)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T197053 WP_069523642.1 NZ_CP071852:2163142-2163420 [Vibrio sp. SCSIO 43155]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWLEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T197053 NZ_CP095538:378973-379269 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11068.46 Da        Isoelectric Point: 10.3074

>AT197053 WP_252044398.1 NZ_CP071852:2162861-2163145 [Vibrio sp. SCSIO 43155]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTKQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT197053 NZ_CP095538:379271-379666 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References