Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2123033..2123561 Replicon chromosome
Accession NZ_CP071852
Organism Vibrio sp. SCSIO 43155

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag J4N44_RS09735 Protein ID WP_005377002.1
Coordinates 2123271..2123561 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag J4N44_RS09730 Protein ID WP_005377003.1
Coordinates 2123033..2123281 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N44_RS09665 (J4N44_09640) 2118068..2118160 - 93 WP_072616896.1 DUF3265 domain-containing protein -
J4N44_RS09670 (J4N44_09645) 2118175..2118582 - 408 WP_005448070.1 hypothetical protein -
J4N44_RS09675 (J4N44_09650) 2118707..2118799 - 93 WP_252044374.1 DUF3265 domain-containing protein -
J4N44_RS09680 (J4N44_09655) 2118891..2119163 - 273 WP_045132854.1 hypothetical protein -
J4N44_RS09685 2119252..2119323 - 72 Protein_1879 DUF3265 domain-containing protein -
J4N44_RS09690 (J4N44_09660) 2119662..2119751 - 90 WP_080640424.1 DUF3265 domain-containing protein -
J4N44_RS09695 (J4N44_09665) 2119773..2120186 - 414 WP_114321754.1 RDD family protein -
J4N44_RS09700 (J4N44_09670) 2120238..2120330 - 93 WP_196333941.1 DUF3265 domain-containing protein -
J4N44_RS09705 (J4N44_09675) 2120345..2121511 - 1167 WP_029811084.1 DUF4062 domain-containing protein -
J4N44_RS09710 (J4N44_09680) 2121554..2121646 - 93 WP_200885265.1 DUF3265 domain-containing protein -
J4N44_RS09715 (J4N44_09685) 2121661..2122293 - 633 WP_045604826.1 hypothetical protein -
J4N44_RS09720 (J4N44_09690) 2122330..2122419 - 90 WP_206171404.1 DUF3265 domain-containing protein -
J4N44_RS09725 (J4N44_09695) 2122437..2122826 - 390 WP_074050579.1 DUF4345 domain-containing protein -
J4N44_RS09730 (J4N44_09700) 2123033..2123281 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4N44_RS09735 (J4N44_09705) 2123271..2123561 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N44_RS09740 (J4N44_09710) 2123706..2124134 - 429 WP_252044377.1 GNAT family N-acetyltransferase -
J4N44_RS09745 (J4N44_09715) 2124288..2125361 - 1074 WP_074050580.1 hypothetical protein -
J4N44_RS09750 2125486..2125615 - 130 Protein_1892 DUF3265 domain-containing protein -
J4N44_RS09755 (J4N44_09720) 2126034..2126125 - 92 Protein_1893 DUF3265 domain-containing protein -
J4N44_RS09760 (J4N44_09725) 2126140..2126553 - 414 WP_074050581.1 hypothetical protein -
J4N44_RS09765 (J4N44_09730) 2126546..2127481 - 936 WP_074050582.1 AAA family ATPase -
J4N44_RS09770 2127623..2127733 - 111 WP_237358001.1 DUF3265 domain-containing protein -
J4N44_RS09775 (J4N44_09740) 2128194..2128385 + 192 WP_074050584.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2104704..2141224 36520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T197052 WP_005377002.1 NZ_CP071852:2123271-2123561 [Vibrio sp. SCSIO 43155]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T197052 NZ_CP095538:316359-316673 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT197052 WP_005377003.1 NZ_CP071852:2123033-2123281 [Vibrio sp. SCSIO 43155]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT197052 NZ_CP095538:316670-317086 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACGCCCAGGCGCTGGAACTGGTCGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References