Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2112325..2112872 Replicon chromosome
Accession NZ_CP071852
Organism Vibrio sp. SCSIO 43155

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J4N44_RS09590 Protein ID WP_252044358.1
Coordinates 2112325..2112627 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag J4N44_RS09595 Protein ID WP_005448240.1
Coordinates 2112615..2112872 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N44_RS09515 (J4N44_09500) 2107386..2107655 - 270 WP_038193591.1 DUF1778 domain-containing protein -
J4N44_RS09520 (J4N44_09505) 2107769..2107858 - 90 WP_252045098.1 DUF3265 domain-containing protein -
J4N44_RS09525 (J4N44_09510) 2107876..2108154 - 279 WP_031852102.1 hypothetical protein -
J4N44_RS09530 (J4N44_09515) 2108246..2108335 - 90 WP_252045099.1 DUF3265 domain-containing protein -
J4N44_RS09535 (J4N44_09520) 2108364..2108834 - 471 WP_188052486.1 hypothetical protein -
J4N44_RS09540 2108968..2109111 - 144 WP_252044349.1 hypothetical protein -
J4N44_RS09545 (J4N44_09530) 2109439..2109528 - 90 WP_071881309.1 DUF3265 domain-containing protein -
J4N44_RS09550 (J4N44_09535) 2109595..2109888 - 294 WP_252044352.1 hypothetical protein -
J4N44_RS09555 (J4N44_09540) 2109960..2110049 - 90 WP_252045100.1 DUF3265 domain-containing protein -
J4N44_RS09560 (J4N44_09545) 2110067..2110399 - 333 WP_009387531.1 hypothetical protein -
J4N44_RS09565 (J4N44_09550) 2110436..2110528 - 93 WP_252044354.1 DUF3265 domain-containing protein -
J4N44_RS09570 (J4N44_09555) 2110543..2110953 - 411 WP_021033956.1 cytidine deaminase -
J4N44_RS09575 (J4N44_09560) 2110995..2111087 - 93 WP_252045101.1 DUF3265 domain-containing protein -
J4N44_RS09580 2111504..2111596 + 93 WP_252045102.1 DUF3265 domain-containing protein -
J4N44_RS09585 (J4N44_09570) 2111643..2112218 + 576 WP_252044356.1 hypothetical protein -
J4N44_RS09590 (J4N44_09575) 2112325..2112627 - 303 WP_252044358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N44_RS09595 (J4N44_09580) 2112615..2112872 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4N44_RS09600 (J4N44_09585) 2112954..2113046 - 93 WP_252044360.1 DUF3265 domain-containing protein -
J4N44_RS09605 (J4N44_09590) 2113074..2113346 - 273 WP_005445731.1 hypothetical protein -
J4N44_RS09610 (J4N44_09595) 2113355..2113759 - 405 WP_069510005.1 type II toxin-antitoxin system YafO family toxin -
J4N44_RS09615 (J4N44_09600) 2113763..2113939 - 177 WP_155414572.1 hypothetical protein -
J4N44_RS09620 (J4N44_09605) 2114088..2114179 - 92 Protein_1866 DUF3265 domain-containing protein -
J4N44_RS09625 (J4N44_09610) 2114194..2114838 - 645 WP_061065168.1 peptidase E -
J4N44_RS09630 (J4N44_09615) 2114880..2114969 - 90 WP_071652537.1 DUF3265 domain-containing protein -
J4N44_RS09635 2115098..2115394 + 297 WP_049538659.1 hypothetical protein -
J4N44_RS09640 2115500..2115616 - 117 WP_103197356.1 DUF3265 domain-containing protein -
J4N44_RS09645 (J4N44_09620) 2115607..2116956 - 1350 WP_252044371.1 hypothetical protein -
J4N44_RS09650 (J4N44_09625) 2117107..2117520 - 414 WP_252044372.1 hypothetical protein -
J4N44_RS09655 (J4N44_09630) 2117549..2117638 - 90 WP_252045103.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2104704..2141224 36520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11657.51 Da        Isoelectric Point: 5.1765

>T197051 WP_252044358.1 NZ_CP071852:c2112627-2112325 [Vibrio sp. SCSIO 43155]
MVEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTSFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T197051 NZ_CP095538:c272998-272534 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGGCAGAAGAAACCCATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT197051 WP_005448240.1 NZ_CP071852:c2112872-2112615 [Vibrio sp. SCSIO 43155]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT197051 NZ_CP095538:c273333-272998 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References