Detailed information of TA system TA197050

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 2106856..2107655
• Replicon: chromosome
• Accession: NZ_CP071852
• Organism: Vibrio sp. SCSIO 43155

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: J4N44_RS09510
• Protein ID: WP_252044347.1
• Coordinates: 2106856..2107389 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0A5HTG5
• Locus tag: J4N44_RS09515
• Protein ID: WP_038193591.1
• Coordinates: 2107386..2107655 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4N44_RS09460 (J4N44_09445)	2102066..2102497	-	432	WP_045490299.1	GNAT family N-acetyltransferase	-
J4N44_RS09465 (J4N44_09450)	2103178..2103297	-	120	WP_252045096.1	DUF3265 domain-containing protein	-
J4N44_RS09470 (J4N44_09455)	2103291..2103563	-	273	WP_050903611.1	hypothetical protein	-
J4N44_RS09475	2103892..2104044	+	153	Protein_1837	IS30 family transposase	-
J4N44_RS09480 (J4N44_09465)	2104088..2104390	-	303	WP_252044342.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J4N44_RS09485 (J4N44_09470)	2104378..2104632	-	255	Protein_1839	type II toxin-antitoxin system Phd/YefM family antitoxin	-
J4N44_RS09490 (J4N44_09475)	2104717..2104794	-	78	WP_226982105.1	DUF3265 domain-containing protein	-
J4N44_RS09495 (J4N44_09480)	2104829..2105245	-	417	WP_226982075.1	hypothetical protein	-
J4N44_RS09500 (J4N44_09485)	2105242..2105676	-	435	WP_050939856.1	T6SS effector amidase Tae4 family protein	-
J4N44_RS09505 (J4N44_09490)	2105936..2106736	-	801	WP_252044345.1	HNH endonuclease	-
J4N44_RS09510 (J4N44_09495)	2106856..2107389	-	534	WP_252044347.1	GNAT family N-acetyltransferase	Toxin
J4N44_RS09515 (J4N44_09500)	2107386..2107655	-	270	WP_038193591.1	DUF1778 domain-containing protein	Antitoxin
J4N44_RS09520 (J4N44_09505)	2107769..2107858	-	90	WP_252045098.1	DUF3265 domain-containing protein	-
J4N44_RS09525 (J4N44_09510)	2107876..2108154	-	279	WP_031852102.1	hypothetical protein	-
J4N44_RS09530 (J4N44_09515)	2108246..2108335	-	90	WP_252045099.1	DUF3265 domain-containing protein	-
J4N44_RS09535 (J4N44_09520)	2108364..2108834	-	471	WP_188052486.1	hypothetical protein	-
J4N44_RS09540	2108968..2109111	-	144	WP_252044349.1	hypothetical protein	-
J4N44_RS09545 (J4N44_09530)	2109439..2109528	-	90	WP_071881309.1	DUF3265 domain-containing protein	-
J4N44_RS09550 (J4N44_09535)	2109595..2109888	-	294	WP_252044352.1	hypothetical protein	-
J4N44_RS09555 (J4N44_09540)	2109960..2110049	-	90	WP_252045100.1	DUF3265 domain-containing protein	-
J4N44_RS09560 (J4N44_09545)	2110067..2110399	-	333	WP_009387531.1	hypothetical protein	-
J4N44_RS09565 (J4N44_09550)	2110436..2110528	-	93	WP_252044354.1	DUF3265 domain-containing protein	-
J4N44_RS09570 (J4N44_09555)	2110543..2110953	-	411	WP_021033956.1	cytidine deaminase	-
J4N44_RS09575 (J4N44_09560)	2110995..2111087	-	93	WP_252045101.1	DUF3265 domain-containing protein	-
J4N44_RS09580	2111504..2111596	+	93	WP_252045102.1	DUF3265 domain-containing protein	-
J4N44_RS09585 (J4N44_09570)	2111643..2112218	+	576	WP_252044356.1	hypothetical protein	-
J4N44_RS09590 (J4N44_09575)	2112325..2112627	-	303	WP_252044358.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	2104704..2141224	36520

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-81)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20165.48 Da
• Isoelectric Point: 9.4355

>T197050 WP_252044347.1 NZ_CP071852:c2107389-2106856 [Vibrio sp. SCSIO 43155]
VSWGKEFVELSKSKHDRNSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAQPMLNQKFAICAFYSVAPSSISRETLPE
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNG
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T197050 NZ_CP095535:91683-91961 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9841.27 Da
• Isoelectric Point: 4.5716

>AT197050 WP_038193591.1 NZ_CP071852:c2107655-2107386 [Vibrio sp. SCSIO 43155]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKAKAPNQALLDAA
KFTDESGIK

Nucleotide

• Length: 270 bp

>AT197050 NZ_CP095535:91414-91683 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0A5HTG5