197045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1004120..1004919 Replicon chromosome
Accession NZ_CP071849
Organism Vibrio sp. SCSIO 43136

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag J4N39_RS19410 Protein ID WP_252023992.1
Coordinates 1004120..1004653 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag J4N39_RS19415 Protein ID WP_252023994.1
Coordinates 1004650..1004919 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N39_RS19375 (J4N39_19385) 999436..1001277 + 1842 WP_252023983.1 M3 family metallopeptidase -
J4N39_RS19380 (J4N39_19390) 1001352..1001978 - 627 WP_252023984.1 LysE family translocator -
J4N39_RS19385 (J4N39_19395) 1002075..1002536 - 462 WP_252023985.1 RidA family protein -
J4N39_RS19390 (J4N39_19400) 1002593..1002970 - 378 WP_252023986.1 hypothetical protein -
J4N39_RS19395 (J4N39_19405) 1002967..1003308 - 342 WP_252023987.1 DUF4144 domain-containing protein -
J4N39_RS19400 (J4N39_19410) 1003482..1003703 + 222 WP_252023988.1 ParD-like family protein -
J4N39_RS19405 (J4N39_19415) 1003696..1003986 + 291 WP_252023990.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4N39_RS19410 (J4N39_19420) 1004120..1004653 - 534 WP_252023992.1 GNAT family N-acetyltransferase Toxin
J4N39_RS19415 (J4N39_19425) 1004650..1004919 - 270 WP_252023994.1 DUF1778 domain-containing protein Antitoxin
J4N39_RS19420 (J4N39_19430) 1005153..1005635 - 483 WP_252023995.1 tetratricopeptide repeat protein -
J4N39_RS19425 (J4N39_19435) 1005831..1006115 + 285 WP_252023997.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
J4N39_RS19430 (J4N39_19440) 1006102..1006371 + 270 WP_252023999.1 type II toxin-antitoxin system YafQ family toxin -
J4N39_RS19435 (J4N39_19445) 1006457..1007405 + 949 Protein_903 IS110 family transposase -
J4N39_RS19440 (J4N39_19450) 1007784..1008098 - 315 WP_252024001.1 DNA-binding transcriptional regulator -
J4N39_RS19445 (J4N39_19455) 1008085..1008417 - 333 WP_252024003.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4N39_RS19450 (J4N39_19460) 1008612..1009229 - 618 WP_252024005.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1007028..1007405 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(2-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20177.46 Da        Isoelectric Point: 9.1580

>T197045 WP_252023992.1 NZ_CP071849:c1004653-1004120 [Vibrio sp. SCSIO 43136]
VSWGKEFVELSKSSHDRNSFDCGEQELNMFIRTQAAKHMQAGISRTMVLPSTQPLLNQKFAICAFYSVAPSSISRETLPT
HMAKKLPRYPVPVFLLAQLAVHKEFHGSGLGKISLIRSLKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNG
HIRMFLPMKTVEQLFTQ

Download         Length: 534 bp

>T197045 NZ_CP095533:c4205431-4205096 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9822.15 Da        Isoelectric Point: 4.3697

>AT197045 WP_252023994.1 NZ_CP071849:c1004919-1004650 [Vibrio sp. SCSIO 43136]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTHVIEEHESIVVKDNVFDEFVAACDKAKAPNSALLEAV
QFTDESGIK

Download         Length: 270 bp

>AT197045 NZ_CP095533:c4205679-4205431 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References