197037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipB(antitoxin)
Location 623782..624182 Replicon chromosome
Accession NZ_CP071848
Organism Vibrio sp. SCSIO 43136

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag J4N39_RS03080 Protein ID WP_252021810.1
Coordinates 623782..623934 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag J4N39_RS03085 Protein ID WP_252021812.1
Coordinates 623937..624182 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N39_RS03055 (J4N39_03055) 619600..620022 + 423 WP_252021802.1 hypothetical protein -
J4N39_RS03060 (J4N39_03060) 620238..620846 + 609 Protein_536 glycerol kinase -
J4N39_RS03065 (J4N39_03065) 621030..621641 + 612 WP_252021804.1 DUF4433 domain-containing protein -
J4N39_RS03070 (J4N39_03070) 621650..622720 + 1071 WP_252021806.1 macro domain-containing protein -
J4N39_RS03075 (J4N39_03075) 622856..623728 + 873 WP_252021808.1 hypothetical protein -
J4N39_RS03080 (J4N39_03080) 623782..623934 - 153 WP_252021810.1 HipA N-terminal domain-containing protein Toxin
J4N39_RS03085 (J4N39_03085) 623937..624182 - 246 WP_252021812.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
J4N39_RS03095 (J4N39_03095) 624774..625259 - 486 WP_252021815.1 SsrA-binding protein SmpB -
J4N39_RS03100 (J4N39_03100) 625364..625795 + 432 WP_252021817.1 SRPBCC family protein -
J4N39_RS03105 (J4N39_03105) 625792..626139 + 348 WP_252021819.1 RnfH family protein -
J4N39_RS03110 (J4N39_03110) 626203..626562 - 360 WP_252021822.1 outer membrane protein assembly factor BamE -
J4N39_RS03115 (J4N39_03115) 626860..628524 - 1665 WP_252021824.1 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-47)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-64)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5544.52 Da        Isoelectric Point: 10.2279

>T197037 WP_252021810.1 NZ_CP071848:c623934-623782 [Vibrio sp. SCSIO 43136]
MKQLLAYMNGELVGALVKRANGAHSFTYDASWLSNEKARPLSLKLQVPII

Download         Length: 153 bp

>T197037 NZ_CP095533:c1961638-1961252 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9452.93 Da        Isoelectric Point: 5.1369

>AT197037 WP_252021812.1 NZ_CP071848:c624182-623937 [Vibrio sp. SCSIO 43136]
MIYSPKQLADFLLLVRQKNRWTQAELAKKVGIKQATISNFENNPDKTTLSTMFKIIQALELKLEVKEPFEVKEPSVDEED
W

Download         Length: 246 bp

>AT197037 NZ_CP095533:c1961262-1960933 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References