Detailed information of TA system TA197035

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1428035..1428580
• Replicon: chromosome
• Accession: NZ_CP071845
• Organism: Vibrio sp. SCSIO 43139

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J4N41_RS06885
• Protein ID: WP_252036463.1
• Coordinates: 1428035..1428331 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7X8YLC8
• Locus tag: J4N41_RS06890
• Protein ID: WP_005526987.1
• Coordinates: 1428338..1428580 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4N41_RS06840 (J4N41_06780)	1423803..1424057	+	255	WP_252036457.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
J4N41_RS06845 (J4N41_06785)	1424050..1424319	+	270	WP_252036458.1	Txe/YoeB family addiction module toxin	-
J4N41_RS06850 (J4N41_06790)	1424498..1424812	+	315	WP_252036459.1	hypothetical protein	-
J4N41_RS06855 (J4N41_06800)	1425369..1425521	+	153	WP_252036460.1	hypothetical protein	-
J4N41_RS06860 (J4N41_06805)	1425522..1426286	+	765	WP_252036619.1	PhzF family phenazine biosynthesis protein	-
J4N41_RS06865 (J4N41_06810)	1426304..1426393	+	90	WP_239871702.1	DUF3265 domain-containing protein	-
J4N41_RS06870 (J4N41_06815)	1426421..1426690	+	270	WP_252036461.1	hypothetical protein	-
J4N41_RS06875 (J4N41_06820)	1426835..1427254	+	420	WP_252036358.1	hypothetical protein	-
J4N41_RS06880 (J4N41_06825)	1427378..1427863	+	486	WP_252036462.1	GNAT family N-acetyltransferase	-
J4N41_RS06885 (J4N41_06830)	1428035..1428331	-	297	WP_252036463.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J4N41_RS06890 (J4N41_06835)	1428338..1428580	-	243	WP_005526987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J4N41_RS06900	1430399..1430542	+	144	WP_252036465.1	hypothetical protein	-
J4N41_RS06905	1430561..1430791	+	231	WP_252036466.1	hypothetical protein	-
J4N41_RS06910 (J4N41_06850)	1431013..1432353	-	1341	WP_252036467.1	BspA family leucine-rich repeat surface protein	-
J4N41_RS06915 (J4N41_06855)	1432392..1432829	-	438	WP_252036468.1	BspA family leucine-rich repeat surface protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1303073..1429922	126849
	-	inside	Integron	-	-	1302066..1428786	126720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11249.88 Da
• Isoelectric Point: 9.8450

>T197035 WP_252036463.1 NZ_CP071845:c1428331-1428035 [Vibrio sp. SCSIO 43139]
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T197035 NZ_CP095533:1336944-1337864 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCCGGCAGGTCAAACTGTTGATGGCCGCTCTGCCGTATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACCGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTACA
AGAGCTTTGCGGATCGCGATACTGATTTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCTGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATCGCCGAGTTGCTGGCTCCAAACTGGGATACAGAGCGGATCGCCACGTTGTACGCGC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8974.16 Da
• Isoelectric Point: 4.7914

>AT197035 WP_005526987.1 NZ_CP071845:c1428580-1428338 [Vibrio sp. SCSIO 43139]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT197035 NZ_CP095533:1336175-1336957 [Escherichia coli]
TTGCCAAACTATCTAAACTGGCTGATGCAGCACACGCTACCCGGCCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CATAGATCGTAAGCTCTCTTATCTCTATGTGAAGAATGGCTGGCTCAGGCGGATCGCTCACGGCGTATACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGGCTTACCGTAGATGTAA
CGTCATTGACTACGGAACTGAAAATTGGCGACCGCCAGTTAGCAGGCAGTGCCCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATATCGTTCGAACATGCCGATGCTCTGTTTCAGGGGATGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGCCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATATTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCCGGCGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X8YLC8