Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1423803..1424319 | Replicon | chromosome |
| Accession | NZ_CP071845 | ||
| Organism | Vibrio sp. SCSIO 43139 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | J4N41_RS06845 | Protein ID | WP_252036458.1 |
| Coordinates | 1424050..1424319 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | J4N41_RS06840 | Protein ID | WP_252036457.1 |
| Coordinates | 1423803..1424057 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4N41_RS06805 (J4N41_06745) | 1418863..1419276 | + | 414 | WP_252036452.1 | hypothetical protein | - |
| J4N41_RS06810 (J4N41_06750) | 1419280..1420602 | - | 1323 | WP_252036453.1 | IS4 family transposase | - |
| J4N41_RS06815 (J4N41_06755) | 1421204..1421380 | + | 177 | WP_252036454.1 | hypothetical protein | - |
| J4N41_RS06820 (J4N41_06760) | 1421491..1422201 | + | 711 | WP_252036455.1 | hypothetical protein | - |
| J4N41_RS06825 (J4N41_06765) | 1422392..1422805 | + | 414 | WP_038162647.1 | RDD family protein | - |
| J4N41_RS06830 (J4N41_06770) | 1422824..1422916 | + | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| J4N41_RS06835 (J4N41_06775) | 1422958..1423584 | + | 627 | WP_252036456.1 | LysE family translocator | - |
| J4N41_RS06840 (J4N41_06780) | 1423803..1424057 | + | 255 | WP_252036457.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| J4N41_RS06845 (J4N41_06785) | 1424050..1424319 | + | 270 | WP_252036458.1 | Txe/YoeB family addiction module toxin | Toxin |
| J4N41_RS06850 (J4N41_06790) | 1424498..1424812 | + | 315 | WP_252036459.1 | hypothetical protein | - |
| J4N41_RS06855 (J4N41_06800) | 1425369..1425521 | + | 153 | WP_252036460.1 | hypothetical protein | - |
| J4N41_RS06860 (J4N41_06805) | 1425522..1426286 | + | 765 | WP_252036619.1 | PhzF family phenazine biosynthesis protein | - |
| J4N41_RS06865 (J4N41_06810) | 1426304..1426393 | + | 90 | WP_239871702.1 | DUF3265 domain-containing protein | - |
| J4N41_RS06870 (J4N41_06815) | 1426421..1426690 | + | 270 | WP_252036461.1 | hypothetical protein | - |
| J4N41_RS06875 (J4N41_06820) | 1426835..1427254 | + | 420 | WP_252036358.1 | hypothetical protein | - |
| J4N41_RS06880 (J4N41_06825) | 1427378..1427863 | + | 486 | WP_252036462.1 | GNAT family N-acetyltransferase | - |
| J4N41_RS06885 (J4N41_06830) | 1428035..1428331 | - | 297 | WP_252036463.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J4N41_RS06890 (J4N41_06835) | 1428338..1428580 | - | 243 | WP_005526987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1303073..1429922 | 126849 | |
| - | flank | IS/Tn | - | - | 1419280..1420602 | 1322 | |
| - | inside | Integron | - | - | 1302066..1428786 | 126720 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10600.93 Da Isoelectric Point: 7.9816
>T197034 WP_252036458.1 NZ_CP071845:1424050-1424319 [Vibrio sp. SCSIO 43139]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T197034 NZ_CP095533:1319751-1320149 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGTGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGTGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9483.63 Da Isoelectric Point: 5.0623
>AT197034 WP_252036457.1 NZ_CP071845:1423803-1424057 [Vibrio sp. SCSIO 43139]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTTRE
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTTRE
LIDE
Download Length: 255 bp
>AT197034 NZ_CP095533:1319455-1319748 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|