Detailed information of TA system TA197033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1414287..1414832
• Replicon: chromosome
• Accession: NZ_CP071845
• Organism: Vibrio sp. SCSIO 43139

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J4N41_RS06765
• Protein ID: WP_252036446.1
• Coordinates: 1414287..1414583 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7X8YLC8
• Locus tag: J4N41_RS06770
• Protein ID: WP_005526987.1
• Coordinates: 1414590..1414832 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4N41_RS06725 (J4N41_06665)	1409336..1409755	+	420	WP_252036440.1	lysozyme inhibitor LprI family protein	-
J4N41_RS06730 (J4N41_06670)	1409876..1410238	+	363	WP_252036441.1	hypothetical protein	-
J4N41_RS06735 (J4N41_06675)	1410483..1410851	+	369	WP_252036442.1	hypothetical protein	-
J4N41_RS06740 (J4N41_06680)	1410854..1411237	+	384	WP_252036443.1	hypothetical protein	-
J4N41_RS06745 (J4N41_06685)	1411700..1411849	+	150	WP_252036444.1	hypothetical protein	-
J4N41_RS06750 (J4N41_06695)	1412748..1413550	+	803	Protein_1301	PhzF family phenazine biosynthesis protein	-
J4N41_RS06755 (J4N41_06700)	1413568..1413657	+	90	WP_239871702.1	DUF3265 domain-containing protein	-
J4N41_RS06760 (J4N41_06705)	1413704..1414111	+	408	WP_252036445.1	GFA family protein	-
J4N41_RS06765 (J4N41_06710)	1414287..1414583	-	297	WP_252036446.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J4N41_RS06770 (J4N41_06715)	1414590..1414832	-	243	WP_005526987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J4N41_RS06775 (J4N41_06720)	1415637..1416071	+	435	WP_252036447.1	hypothetical protein	-
J4N41_RS06780	1416098..1416190	+	93	WP_252036448.1	DUF3265 domain-containing protein	-
J4N41_RS06785 (J4N41_06725)	1416230..1416634	+	405	WP_252036449.1	GFA family protein	-
J4N41_RS06790 (J4N41_06730)	1416763..1417233	+	471	WP_252036393.1	hypothetical protein	-
J4N41_RS06795 (J4N41_06735)	1417864..1418160	+	297	WP_252036450.1	DUF6506 family protein	-
J4N41_RS06800 (J4N41_06740)	1418318..1418728	+	411	WP_252036451.1	hypothetical protein	-
J4N41_RS06805 (J4N41_06745)	1418863..1419276	+	414	WP_252036452.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1303073..1429922	126849
	-	flank	IS/Tn	-	-	1419280..1420602	1322
	-	inside	Integron	-	-	1302066..1428786	126720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11253.88 Da
• Isoelectric Point: 9.6430

>T197033 WP_252036446.1 NZ_CP071845:c1414583-1414287 [Vibrio sp. SCSIO 43139]
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPAGKHTAYFTKEDC
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T197033 NZ_CP095533:919223-920170 [Escherichia coli]
ATGGATGATTTAACCACTCTTTTTTCTGAAGTGGCTGACGCGCTTGGTATTGAGTCTGTCGCAATTGTGGAAAAAGATCA
CTATATCGTTGAGCTTTTGCAATTGCTTAAACCTCTGGTGTTCGATACTCATCAATTGGTGTTTGCCGGAGGAACCGCTC
TGGCAAAATCAGGTGTCGCACTTAATCGCATGTCGGAAGATGTGGATATCAAACTGGTGCCTAAGGATGCATTTCAGGCA
CTTTCCCGCACTCAGCGAAAAAATACCCGTAAAGAAATTGTTCAGGCAGTTTCCAGTGCAATAGCTTCATCGGGTGTGTT
CAATTTTGATGATGATTACCCAAAAGTGACGCGGGATGAATATCGTTATAATGACATACCTGTTCGTTATCCACAGCGAG
TGGTGCAGGCACCTTGTTTGCGTCCTTTTATCCGGCTGGAATTGATGGAAGCGAAGTTACTGGAGCCTTCTGAATTACGG
GATATTCATTCACTGGTAACAGGGATCACGGGAAAAGCGGCTATTGTTTCAGCGTTTCCATGCGCAACTATCATTAGCAC
ACAGGCTGAAAAGCTGGTGGCGATGTTACGTCGTACTGCGGCAGTTGTGCGAGATGTTGAGCGATTTGATGATGCATCGC
TGGTACGTCATATCTACGATACAAACTGTATTGTTGAGACGAGTCATGTTGATATGAGTCTGCTCGTTGATTTTGTTCAA
CAAACTATTGAGCAGGACATTCAGCGTTACGGCAACCAGTACCCGCAGTTTTGCGCGTCTCCAGTTGATGAGCTAAAAAT
GGGACTGGATGAGTTGGCGAACAATCCTCTCTACCAGATGCGCTATCAGCAGTTTGTTTCGCCAATGGTGTATGGAGAGC
GAAAGATCACATGGGATGAGGTTTACTCCAGGTTTAGGAGCTTAGCGCTAGCCATCCTGAATGCTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8974.16 Da
• Isoelectric Point: 4.7914

>AT197033 WP_005526987.1 NZ_CP071845:c1414832-1414590 [Vibrio sp. SCSIO 43139]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT197033 NZ_CP095533:918835-919230 [Escherichia coli]
ATGACGATAAAAGCACGCATTCAGTCACGACTGAAACGTTCTAAACGTTACGTATTCACTCGTGACGACTTTAAAGATAT
TGCAGGCTACGATCAGGTTGGTCGGGTATTGCGCGAGCTTGTCAGGGAAGGGCAACTGTTGAAGGTTGGTTATGGCGTGT
ATACCAAAGCACGGCGGAACGGTATTACAGGCAAGGTAATGCCAGCGGCTCCCGGAGGCTCTTCAGCGGTGATTGTCGAA
ACGCTGGAACGCCTGAAAGTACGCTATCGTTTTGCTGGCGCAACGCAGGCATACAATAGCGGTACTTCTACGCAGATCCC
AGCTTCACCCGAGATAAAAACCCCCCGGCGTTTTAAACGCGTATTATCTGTAGGGAACAGCAGATTAAATGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A7X8YLC8