Detailed information of TA system TA197030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1344159..1344704
• Replicon: chromosome
• Accession: NZ_CP071845
• Organism: Vibrio sp. SCSIO 43139

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A151KUE6
• Locus tag: J4N41_RS06225
• Protein ID: WP_038939651.1
• Coordinates: 1344159..1344455 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: J4N41_RS06230
• Protein ID: WP_239866745.1
• Coordinates: 1344462..1344704 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4N41_RS06180 (J4N41_06155)	1339270..1339620	+	351	WP_252036372.1	hypothetical protein	-
J4N41_RS06185 (J4N41_06160)	1340235..1340544	+	310	Protein_1187	DUF4144 family protein	-
J4N41_RS06190 (J4N41_06165)	1340687..1341184	+	498	WP_170966842.1	hypothetical protein	-
J4N41_RS06195 (J4N41_06170)	1341322..1341693	+	372	WP_252036373.1	RidA family protein	-
J4N41_RS06200 (J4N41_06175)	1341845..1342234	+	390	WP_252036374.1	hypothetical protein	-
J4N41_RS06205 (J4N41_06180)	1342378..1342833	-	456	WP_252036375.1	hypothetical protein	-
J4N41_RS06210	1342916..1343098	+	183	WP_252036376.1	hypothetical protein	-
J4N41_RS06215 (J4N41_06185)	1343440..1343580	+	141	WP_252036377.1	hypothetical protein	-
J4N41_RS06220 (J4N41_06190)	1343640..1343987	+	348	WP_239866754.1	hypothetical protein	-
J4N41_RS06225 (J4N41_06195)	1344159..1344455	-	297	WP_038939651.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J4N41_RS06230 (J4N41_06200)	1344462..1344704	-	243	WP_239866745.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J4N41_RS06235 (J4N41_06205)	1344958..1345695	+	738	WP_239876928.1	SDR family oxidoreductase	-
J4N41_RS06240	1345673..1345810	+	138	WP_239876929.1	DUF3265 domain-containing protein	-
J4N41_RS06245 (J4N41_06210)	1347119..1347367	+	249	WP_252036378.1	hypothetical protein	-
J4N41_RS06250 (J4N41_06215)	1347596..1347832	+	237	WP_252036379.1	hypothetical protein	-
J4N41_RS06255 (J4N41_06220)	1348223..1348885	+	663	WP_252036380.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1303073..1429922	126849
	-	inside	Integron	-	-	1302066..1428786	126720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11278.93 Da
• Isoelectric Point: 9.6269

>T197030 WP_038939651.1 NZ_CP071845:c1344455-1344159 [Vibrio sp. SCSIO 43139]
MQKNKYKLSKLAQTHLQKIKNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T197030 NZ_CP095533:746262-746435 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9030.23 Da
• Isoelectric Point: 4.7914

>AT197030 WP_239866745.1 NZ_CP071845:c1344704-1344462 [Vibrio sp. SCSIO 43139]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLVQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT197030 NZ_CP095533:745938-746234 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A151KUE6