Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 79949..80465 | Replicon | plasmid unnamed |
| Accession | NZ_CP071844 | ||
| Organism | Vibrio sp. SCSIO 43009 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | U2ZZV8 |
| Locus tag | J4N43_RS24240 | Protein ID | WP_005464459.1 |
| Coordinates | 80196..80465 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A0P7ESB6 |
| Locus tag | J4N43_RS24235 | Protein ID | WP_017634119.1 |
| Coordinates | 79949..80203 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4N43_RS24200 (J4N43_24070) | 75494..75586 | + | 93 | WP_113795351.1 | DUF3265 domain-containing protein | - |
| J4N43_RS24205 (J4N43_24075) | 75623..76288 | + | 666 | WP_252094212.1 | DUF6338 family protein | - |
| J4N43_RS24210 (J4N43_24080) | 76438..76530 | + | 93 | WP_197072411.1 | DUF3265 domain-containing protein | - |
| J4N43_RS24215 (J4N43_24085) | 76562..77341 | + | 780 | WP_252094213.1 | hypothetical protein | - |
| J4N43_RS24220 (J4N43_24090) | 77370..78324 | - | 955 | Protein_79 | IS110 family transposase | - |
| J4N43_RS24225 (J4N43_24095) | 78668..79243 | + | 576 | WP_252094214.1 | hypothetical protein | - |
| J4N43_RS24230 (J4N43_24100) | 79361..79756 | + | 396 | WP_252094215.1 | DUF3465 domain-containing protein | - |
| J4N43_RS24235 (J4N43_24105) | 79949..80203 | + | 255 | WP_017634119.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| J4N43_RS24240 (J4N43_24110) | 80196..80465 | + | 270 | WP_005464459.1 | Txe/YoeB family addiction module toxin | Toxin |
| J4N43_RS24245 (J4N43_24115) | 80508..80597 | + | 90 | WP_081586720.1 | DUF3265 domain-containing protein | - |
| J4N43_RS24250 (J4N43_24120) | 80679..80936 | + | 258 | WP_017634117.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J4N43_RS24255 (J4N43_24125) | 80924..81226 | + | 303 | WP_136976192.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J4N43_RS24260 | 81261..81349 | + | 89 | Protein_87 | DUF3265 domain-containing protein | - |
| J4N43_RS24265 (J4N43_24130) | 81446..81880 | + | 435 | WP_017634115.1 | hypothetical protein | - |
| J4N43_RS24270 (J4N43_24135) | 81995..82447 | + | 453 | WP_054579183.1 | GIY-YIG nuclease family protein | - |
| J4N43_RS24275 (J4N43_24140) | 82673..82969 | + | 297 | WP_053307322.1 | YkgJ family cysteine cluster protein | - |
| J4N43_RS24280 (J4N43_24145) | 83415..84977 | - | 1563 | WP_025998574.1 | sensor domain-containing diguanylate cyclase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..135905 | 135905 | |
| - | inside | Integron | - | - | 71755..80936 | 9181 | |
| - | flank | IS/Tn | - | - | 77444..78133 | 689 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10614.96 Da Isoelectric Point: 7.9816
>T197028 WP_005464459.1 NZ_CP071844:80196-80465 [Vibrio sp. SCSIO 43009]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T197028 NZ_CP095529:4180245-4180709 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGGCAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGGCAGAAGAAACCCATTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9455.57 Da Isoelectric Point: 4.7483
>AT197028 WP_017634119.1 NZ_CP071844:79949-80203 [Vibrio sp. SCSIO 43009]
MRIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTAQE
LIDE
MRIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTAQE
LIDE
Download Length: 255 bp
>AT197028 NZ_CP095529:4179910-4180245 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U2ZZV8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0P7ESB6 |