Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1434545..1435104 Replicon chromosome
Accession NZ_CP071840
Organism Vibrio sp. SCSIO 43097

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag J4N40_RS07315 Protein ID WP_005398411.1
Coordinates 1434545..1434823 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag J4N40_RS07320 Protein ID WP_005398409.1
Coordinates 1434820..1435104 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N40_RS07275 (J4N40_07190) 1429774..1429864 + 91 Protein_1355 DUF3265 domain-containing protein -
J4N40_RS07280 (J4N40_07195) 1430385..1431383 + 999 WP_104979324.1 alpha/beta fold hydrolase -
J4N40_RS07285 (J4N40_07200) 1431398..1431490 + 93 WP_115386054.1 DUF3265 domain-containing protein -
J4N40_RS07290 1431951..1432040 + 90 WP_080262357.1 DUF3265 domain-containing protein -
J4N40_RS07295 (J4N40_07210) 1432067..1432576 + 510 WP_104979320.1 DUF4145 domain-containing protein -
J4N40_RS07300 (J4N40_07215) 1432718..1433029 + 312 WP_136977026.1 hypothetical protein -
J4N40_RS07305 (J4N40_07220) 1433179..1433727 + 549 WP_104979317.1 hypothetical protein -
J4N40_RS07310 (J4N40_07225) 1433872..1434408 + 537 WP_104975413.1 nucleotidyltransferase family protein -
J4N40_RS07315 (J4N40_07230) 1434545..1434823 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
J4N40_RS07320 (J4N40_07235) 1434820..1435104 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J4N40_RS07325 (J4N40_07240) 1435181..1435273 + 93 WP_104975412.1 DUF3265 domain-containing protein -
J4N40_RS07330 (J4N40_07245) 1435425..1435841 + 417 WP_104979313.1 hypothetical protein -
J4N40_RS07335 (J4N40_07250) 1435838..1436224 + 387 WP_104979311.1 hypothetical protein -
J4N40_RS07340 1436252..1436317 + 66 Protein_1368 DUF3265 domain-containing protein -
J4N40_RS07345 (J4N40_07255) 1436398..1437285 + 888 WP_250654446.1 phosphotransferase -
J4N40_RS07350 (J4N40_07260) 1437474..1437872 + 399 WP_042524338.1 SMI1/KNR4 family protein -
J4N40_RS07355 (J4N40_07265) 1438019..1438309 + 291 WP_042523463.1 hypothetical protein -
J4N40_RS07360 (J4N40_07270) 1438533..1438913 + 381 WP_104979310.1 STAS/SEC14 domain-containing protein -
J4N40_RS07365 (J4N40_07275) 1439497..1439586 + 90 WP_077345960.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vxsC / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1292420..1742711 450291
- inside Integron - - 1336772..1465600 128828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T197024 WP_005398411.1 NZ_CP071840:c1434823-1434545 [Vibrio sp. SCSIO 43097]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T197024 NZ_CP095529:c2445662-2444340 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACCGTCGCTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT197024 WP_005398409.1 NZ_CP071840:c1435104-1434820 [Vibrio sp. SCSIO 43097]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT197024 NZ_CP095529:c2445928-2445662 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGTATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References