Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1377572..1378119 Replicon chromosome
Accession NZ_CP071840
Organism Vibrio sp. SCSIO 43097

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag J4N40_RS06705 Protein ID WP_005377013.1
Coordinates 1377817..1378119 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag J4N40_RS06700 Protein ID WP_005377012.1
Coordinates 1377572..1377829 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4N40_RS06640 1372733..1372843 + 111 WP_238764820.1 DUF3265 domain-containing protein -
J4N40_RS06645 (J4N40_06620) 1372881..1373171 + 291 WP_042523463.1 hypothetical protein -
J4N40_RS06650 (J4N40_06625) 1373312..1373857 + 546 WP_171346386.1 hypothetical protein -
J4N40_RS06655 (J4N40_06630) 1373872..1373964 + 93 WP_140065282.1 DUF3265 domain-containing protein -
J4N40_RS06660 (J4N40_06635) 1373996..1374391 + 396 WP_042524285.1 ACT domain-containing protein -
J4N40_RS06665 (J4N40_06640) 1374547..1375023 + 477 WP_054730962.1 GNAT family N-acetyltransferase -
J4N40_RS06670 (J4N40_06645) 1375241..1375771 + 531 WP_115386118.1 hypothetical protein -
J4N40_RS06675 (J4N40_06650) 1376041..1376133 + 93 WP_072617168.1 DUF3265 domain-containing protein -
J4N40_RS06680 (J4N40_06655) 1376162..1376674 + 513 WP_115386121.1 hypothetical protein -
J4N40_RS06685 (J4N40_06660) 1376689..1376781 + 93 WP_115386120.1 DUF3265 domain-containing protein -
J4N40_RS06690 (J4N40_06665) 1376811..1377383 + 573 WP_025768910.1 hypothetical protein -
J4N40_RS06695 (J4N40_06670) 1377398..1377490 + 93 WP_115386119.1 DUF3265 domain-containing protein -
J4N40_RS06700 (J4N40_06675) 1377572..1377829 + 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4N40_RS06705 (J4N40_06680) 1377817..1378119 + 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4N40_RS06710 (J4N40_06685) 1378155..1378247 + 93 WP_115386088.1 DUF3265 domain-containing protein -
J4N40_RS06715 (J4N40_06690) 1378276..1378917 + 642 WP_115386087.1 hypothetical protein -
J4N40_RS06720 1378875..1379030 + 156 WP_238844095.1 DUF3265 domain-containing protein -
J4N40_RS06725 (J4N40_06695) 1379166..1379519 + 354 WP_147289569.1 hypothetical protein -
J4N40_RS06730 (J4N40_06700) 1379550..1380521 - 972 WP_050550131.1 IS30 family transposase -
J4N40_RS06735 1380604..1380675 + 72 Protein_1247 DUF3265 domain-containing protein -
J4N40_RS06740 (J4N40_06705) 1380769..1381230 + 462 WP_025796455.1 GIY-YIG nuclease family protein -
J4N40_RS06745 (J4N40_06710) 1381345..1381665 + 321 WP_053300079.1 hypothetical protein -
J4N40_RS06750 (J4N40_06715) 1382220..1382309 + 90 WP_115386422.1 DUF3265 domain-containing protein -
J4N40_RS06755 (J4N40_06720) 1382343..1382738 + 396 WP_115386085.1 DUF3465 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vxsC / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1292420..1742711 450291
- flank IS/Tn - - 1379550..1380482 932
- inside Integron - - 1336772..1465600 128828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T197023 WP_005377013.1 NZ_CP071840:1377817-1378119 [Vibrio sp. SCSIO 43097]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T197023 NZ_CP095529:c2395036-2394758 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT197023 WP_005377012.1 NZ_CP071840:1377572-1377829 [Vibrio sp. SCSIO 43097]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT197023 NZ_CP095529:c2394758-2394474 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References