Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 77328..77977 Replicon plasmid unnamed5
Accession NZ_CP071829
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J4G50_RS39305 Protein ID WP_027813527.1
Coordinates 77328..77738 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6P2T8K5
Locus tag J4G50_RS39310 Protein ID WP_027813526.1
Coordinates 77735..77977 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS39260 72359..72649 - 291 WP_027813562.1 hypothetical protein -
J4G50_RS39265 72731..73402 - 672 WP_034176084.1 hypothetical protein -
J4G50_RS39270 73618..73872 - 255 WP_046544062.1 hypothetical protein -
J4G50_RS39275 73882..74112 - 231 WP_027813533.1 hypothetical protein -
J4G50_RS39280 74123..75208 - 1086 WP_027813532.1 hypothetical protein -
J4G50_RS39285 75253..75558 - 306 WP_027813531.1 hypothetical protein -
J4G50_RS39290 75579..76232 - 654 WP_027813530.1 helix-turn-helix domain-containing protein -
J4G50_RS39295 76420..76620 - 201 WP_034176085.1 hypothetical protein -
J4G50_RS39300 76669..77016 - 348 WP_027813528.1 hypothetical protein -
J4G50_RS39305 77328..77738 - 411 WP_027813527.1 type II toxin-antitoxin system VapC family toxin Toxin
J4G50_RS39310 77735..77977 - 243 WP_027813526.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J4G50_RS39315 78072..79121 - 1050 WP_027813525.1 non-homologous end-joining DNA ligase -
J4G50_RS39320 79524..80195 + 672 WP_027813524.1 AAA family ATPase -
J4G50_RS39325 80195..81160 + 966 WP_027813523.1 ParB/RepB/Spo0J family partition protein -
J4G50_RS39330 81903..82760 + 858 WP_027813522.1 replication initiator protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..152479 152479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(12-50)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14869.13 Da        Isoelectric Point: 4.8604

>T197020 WP_027813527.1 NZ_CP071829:c77738-77328 [Burkholderia anthina]
MTLYLLDTNILSNVIRDPRGACATRIGETPPEQVCTSIIVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRAELEKQGQLIDANDMLIAAHALAVDAVLVTDNTAEFTRIAGLPVENWLRPAT

Download         Length: 411 bp

>T197020 NZ_CP095529:c2114741-2114634 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9375.64 Da        Isoelectric Point: 4.6856

>AT197020 WP_027813526.1 NZ_CP071829:c77977-77735 [Burkholderia anthina]
MPNHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDEIFPDIEDLPPEPVDIE

Download         Length: 243 bp

>AT197020 NZ_CP095529:2114794-2114855 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGGTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P2T8K5

References