Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1279..1873 Replicon plasmid unnamed5
Accession NZ_CP071829
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name PumA Uniprot ID A0A228JB64
Locus tag J4G50_RS38935 Protein ID WP_027811055.1
Coordinates 1580..1873 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A228JAU5
Locus tag J4G50_RS38930 Protein ID WP_027811056.1
Coordinates 1279..1578 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS38920 54..557 + 504 WP_143277545.1 hypothetical protein -
J4G50_RS38925 805..1116 + 312 WP_027811057.1 hypothetical protein -
J4G50_RS38930 1279..1578 - 300 WP_027811056.1 putative addiction module antidote protein Antitoxin
J4G50_RS38935 1580..1873 - 294 WP_027811055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G50_RS38940 1978..2121 - 144 WP_154233621.1 hypothetical protein -
J4G50_RS38945 2178..2399 - 222 WP_027811054.1 DUF3717 domain-containing protein -
J4G50_RS38950 2444..2995 - 552 WP_077186813.1 hypothetical protein -
J4G50_RS38955 2970..3236 - 267 WP_027811052.1 hypothetical protein -
J4G50_RS38960 4280..6409 - 2130 WP_039350079.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..152479 152479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10854.50 Da        Isoelectric Point: 10.6086

>T197019 WP_027811055.1 NZ_CP071829:c1873-1580 [Burkholderia anthina]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDMKPVGAGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

>T197019 NZ_CP095529:c2114206-2114099 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10716.01 Da        Isoelectric Point: 4.6364

>AT197019 WP_027811056.1 NZ_CP071829:c1578-1279 [Burkholderia anthina]
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp

>AT197019 NZ_CP095529:2114254-2114320 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228JB64

Antitoxin

Source ID Structure
AlphaFold DB A0A228JAU5

References