Detailed information of TA system TA197016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2275484..2276007
• Replicon: chromosome
• Accession: NZ_CP071826
• Organism: Burkholderia anthina strain 1CH1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J4G50_RS29155
• Protein ID: WP_207999153.1
• Coordinates: 2275741..2276007 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1YYI3
• Locus tag: J4G50_RS29150
• Protein ID: WP_012366507.1
• Coordinates: 2275484..2275744 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4G50_RS29130	2271592..2272980	+	1389	WP_207999149.1	MFS transporter	-
J4G50_RS29135	2273335..2274546	+	1212	WP_207999151.1	winged helix DNA-binding domain-containing protein	-
J4G50_RS29140	2274614..2274832	-	219	WP_006751720.1	DUF1653 domain-containing protein	-
J4G50_RS29145	2274888..2275331	-	444	WP_096508115.1	GNAT family N-acetyltransferase	-
J4G50_RS29150	2275484..2275744	+	261	WP_012366507.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J4G50_RS29155	2275741..2276007	+	267	WP_207999153.1	Txe/YoeB family addiction module toxin	Toxin
J4G50_RS29160	2276044..2276424	-	381	WP_207999155.1	DUF4087 domain-containing protein	-
J4G50_RS29165	2276628..2277458	+	831	WP_207999157.1	extracellular solute-binding protein	-
J4G50_RS29170	2277476..2278099	+	624	WP_207999158.1	HAD hydrolase-like protein	-
J4G50_RS29175	2278488..2279057	+	570	WP_207999160.1	DUF4142 domain-containing protein	-
J4G50_RS29180	2279166..2279765	-	600	WP_207999162.1	GNAT family N-acetyltransferase	-
J4G50_RS29185	2279847..2280761	-	915	WP_207999164.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10553.93 Da
• Isoelectric Point: 9.4575

>T197016 WP_207999153.1 NZ_CP071826:2275741-2276007 [Burkholderia anthina]
MSVRRVLFTSDARDDYVYWQWQDRKTLKRINQLVREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYA

Nucleotide

• Length: 267 bp

>T197016 NZ_CP095529:c1305191-1304973 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9759.03 Da
• Isoelectric Point: 6.0735

>AT197016 WP_012366507.1 NZ_CP071826:2275484-2275744 [Burkholderia anthina]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQEYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Nucleotide

• Length: 261 bp

>AT197016 NZ_CP095529:c1305591-1305217 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A2S9KUE4