Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2214633..2215288 Replicon chromosome
Accession NZ_CP071826
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J4G50_RS28885 Protein ID WP_096501450.1
Coordinates 2214633..2215052 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J4G50_RS28890 Protein ID WP_096501452.1
Coordinates 2215049..2215288 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS28860 2209890..2210684 + 795 WP_207999112.1 helix-turn-helix domain-containing protein -
J4G50_RS28865 2210883..2211815 + 933 WP_207999113.1 EamA family transporter -
J4G50_RS28870 2212157..2212729 + 573 WP_096501444.1 permease -
J4G50_RS28875 2212829..2212963 - 135 WP_096501446.1 entericidin A/B family lipoprotein -
J4G50_RS28880 2213196..2214491 + 1296 WP_207999114.1 aspartate carbamoyltransferase -
J4G50_RS28885 2214633..2215052 - 420 WP_096501450.1 type II toxin-antitoxin system VapC family toxin Toxin
J4G50_RS28890 2215049..2215288 - 240 WP_096501452.1 Arc family DNA-binding protein Antitoxin
J4G50_RS28895 2215609..2217852 + 2244 WP_207999115.1 TonB-dependent siderophore receptor -
J4G50_RS28900 2217856..2218611 + 756 WP_174925907.1 sel1 repeat family protein -
J4G50_RS28905 2218608..2219291 + 684 WP_096501458.1 Fe2+-dependent dioxygenase -
J4G50_RS28910 2219642..2219881 + 240 WP_207999116.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J4G50_RS28915 2219878..2220273 + 396 WP_208000564.1 PIN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14900.15 Da        Isoelectric Point: 5.1532

>T197015 WP_096501450.1 NZ_CP071826:c2215052-2214633 [Burkholderia anthina]
MILVDTNVIAEPLRREPSAAVIAWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLQQSIEQRVVPLFRGRILPFDE
AASHAYASLRAQARAMGSAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAG

Download         Length: 420 bp

>T197015 NZ_CP095529:1080486-1080827 [Escherichia coli]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCTGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGATACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCGGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8693.91 Da        Isoelectric Point: 6.4666

>AT197015 WP_096501452.1 NZ_CP071826:c2215288-2215049 [Burkholderia anthina]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVRPGGRPRLGTLLVEIGREAGGIDLEIQRGTAPTDPMSFE

Download         Length: 240 bp

>AT197015 NZ_CP095529:1080837-1081136 [Escherichia coli]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACTCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCGAATGGTAAGAGAATTGCATTTCAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References