Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2020816..2022566 Replicon chromosome
Accession NZ_CP071826
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag J4G50_RS28070 Protein ID WP_207999012.1
Coordinates 2021670..2022566 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag J4G50_RS28065 Protein ID WP_096501132.1
Coordinates 2020816..2021673 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS28045 2015956..2017446 - 1491 WP_096501124.1 aldehyde dehydrogenase -
J4G50_RS28050 2017527..2018366 - 840 WP_096501126.1 aspartate dehydrogenase -
J4G50_RS28055 2018359..2020029 - 1671 WP_207999011.1 thiamine pyrophosphate-binding protein -
J4G50_RS28060 2020022..2020819 - 798 WP_096501130.1 SDR family oxidoreductase -
J4G50_RS28065 2020816..2021673 - 858 WP_096501132.1 IclR family transcriptional regulator Antitoxin
J4G50_RS28070 2021670..2022566 - 897 WP_207999012.1 alpha/beta fold hydrolase Toxin
J4G50_RS28075 2022585..2023112 - 528 WP_174925809.1 cupin domain-containing protein -
J4G50_RS28080 2023147..2023917 - 771 WP_207999013.1 SDR family oxidoreductase -
J4G50_RS28085 2023910..2024980 - 1071 WP_096501140.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
J4G50_RS28090 2025035..2025346 - 312 WP_096501142.1 hypothetical protein -
J4G50_RS28095 2025348..2025665 - 318 WP_014898924.1 non-heme iron oxygenase ferredoxin subunit -
J4G50_RS28100 2026113..2027192 + 1080 WP_207999014.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30779.85 Da        Isoelectric Point: 7.3896

>T197014 WP_207999012.1 NZ_CP071826:c2022566-2021670 [Burkholderia anthina]
MSVIDKRERDRTAAFATLLGQFPEQRCEAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRALAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLSRAVPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLEELGPAGLAEQRSGNMLSGFASDEARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSSLIDGFCRQCDRQRGLE

Download         Length: 897 bp

>T197014 NZ_CP095529:c782724-782572 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31404.86 Da        Isoelectric Point: 6.6561

>AT197014 WP_096501132.1 NZ_CP071826:c2021673-2020816 [Burkholderia anthina]
MSEPLQRQDAENAKAEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLTELRALYPEGALNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQRIVACITVTVP
RPEIDASLIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT197014 NZ_CP095529:782773-782830 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References