Detailed information of TA system TA197013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1692203..1692842
• Replicon: chromosome
• Accession: NZ_CP071826
• Organism: Burkholderia anthina strain 1CH1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J4G50_RS26675
• Protein ID: WP_172441857.1
• Coordinates: 1692203..1692619 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A4V8GAU9
• Locus tag: J4G50_RS26680
• Protein ID: WP_014899176.1
• Coordinates: 1692606..1692842 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4G50_RS26650	1687361..1688473	-	1113	WP_207998847.1	nitronate monooxygenase	-
J4G50_RS26655	1688470..1689387	-	918	WP_207998848.1	enoyl-CoA hydratase	-
J4G50_RS26660	1689396..1690193	-	798	WP_207998849.1	ketoacid CoA transferase	-
J4G50_RS26665	1690204..1691097	-	894	WP_207998850.1	CoA transferase subunit A	-
J4G50_RS26670	1691107..1692003	-	897	WP_207998851.1	VOC family protein	-
J4G50_RS26675	1692203..1692619	-	417	WP_172441857.1	type II toxin-antitoxin system VapC family toxin	Toxin
J4G50_RS26680	1692606..1692842	-	237	WP_014899176.1	DNA-binding protein	Antitoxin
J4G50_RS26685	1693188..1693841	-	654	WP_096499589.1	hypothetical protein	-
J4G50_RS26690	1694615..1695019	-	405	WP_207998852.1	DUF1634 domain-containing protein	-
J4G50_RS26695	1695016..1695867	-	852	WP_207998853.1	TSUP family transporter	-
J4G50_RS26700	1695881..1696624	-	744	WP_207998854.1	UTRA domain-containing protein	-
J4G50_RS26705	1696687..1697460	-	774	WP_207998855.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15421.60 Da
• Isoelectric Point: 6.8816

>T197013 WP_172441857.1 NZ_CP071826:c1692619-1692203 [Burkholderia anthina]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHQQASALEAWMAMILSGYASNI
LPVDIETSQTWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T197013 NZ_CP095529:589359-589649 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8668.70 Da
• Isoelectric Point: 5.0628

>AT197013 WP_014899176.1 NZ_CP071826:c1692842-1692606 [Burkholderia anthina]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT197013 NZ_CP095529:589127-589369 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCTACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A4V8GAU9