Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1045087..1045733 Replicon chromosome
Accession NZ_CP071826
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J4G50_RS23785 Protein ID WP_096499254.1
Coordinates 1045326..1045733 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J4G50_RS23780 Protein ID WP_096499256.1
Coordinates 1045087..1045329 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS23745 1040150..1040374 - 225 WP_011355611.1 hypothetical protein -
J4G50_RS23750 1040679..1041368 + 690 WP_208000228.1 DUF969 family protein -
J4G50_RS23755 1041365..1042315 + 951 WP_208000229.1 DUF979 family protein -
J4G50_RS23760 1042326..1043348 + 1023 WP_208000230.1 DUF2891 family protein -
J4G50_RS23765 1043498..1043821 + 324 WP_174927413.1 hypothetical protein -
J4G50_RS23770 1043928..1044089 + 162 Protein_951 asparaginase -
J4G50_RS23775 1044133..1044822 - 690 WP_096499258.1 phospholipase -
J4G50_RS23780 1045087..1045329 + 243 WP_096499256.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J4G50_RS23785 1045326..1045733 + 408 WP_096499254.1 type II toxin-antitoxin system VapC family toxin Toxin
J4G50_RS23790 1045830..1047317 - 1488 WP_208000231.1 aldehyde dehydrogenase family protein -
J4G50_RS23795 1047346..1047924 - 579 WP_208000232.1 thioesterase family protein -
J4G50_RS23800 1048187..1049317 + 1131 WP_208000233.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14731.74 Da        Isoelectric Point: 5.9809

>T197011 WP_096499254.1 NZ_CP071826:1045326-1045733 [Burkholderia anthina]
MKFLLDTNAVIAILKGDPAVLARLHRHQPADFGMPAIVAHELYYGAYKSQRVEANLARVAGLQFEVVSFDAEDAQHAGEI
RAQLTAAGTPIGPYDALIAGQARARRLVLVTHNTREFEGVTALEVEDWLAGPREN

Download         Length: 408 bp

>T197011 NZ_CP095529:545032-545406 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTTGG
CCGTCTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8930.07 Da        Isoelectric Point: 4.7628

>AT197011 WP_096499256.1 NZ_CP071826:1045087-1045329 [Burkholderia anthina]
METAKIFRHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAATTEPAAQERPGLDVFE

Download         Length: 243 bp

>AT197011 NZ_CP095529:544574-544942 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTACTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAGCTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTTACCTGCAAAGCCGATACCCTCGGCAGTCG
AGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References