Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 3773873..3774510 Replicon chromosome
Accession NZ_CP071825
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J4G50_RS18275 Protein ID WP_174926792.1
Coordinates 3773873..3774274 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag J4G50_RS18280 Protein ID WP_096506786.1
Coordinates 3774274..3774510 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS18265 3771249..3772385 + 1137 WP_096506678.1 alginate lyase family protein -
J4G50_RS18270 3772416..3773804 + 1389 WP_096506679.1 L-serine ammonia-lyase -
J4G50_RS18275 3773873..3774274 - 402 WP_174926792.1 type II toxin-antitoxin system VapC family toxin Toxin
J4G50_RS18280 3774274..3774510 - 237 WP_096506786.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J4G50_RS18285 3774826..3776529 + 1704 WP_207997647.1 thiamine pyrophosphate-binding protein -
J4G50_RS18290 3776526..3777617 + 1092 WP_207997648.1 ADP-heptose--LPS heptosyltransferase -
J4G50_RS18295 3777664..3778698 - 1035 WP_096506683.1 helix-turn-helix domain-containing protein -
J4G50_RS18300 3778905..3779444 - 540 WP_096506684.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14997.20 Da        Isoelectric Point: 5.6577

>T197008 WP_174926792.1 NZ_CP071825:c3774274-3773873 [Burkholderia anthina]
MPRYMLDTNMCIYLMRHQPEPVARRFAQCYTGDVVMSAITYAELEYGVAVCASPARERRNLAALIDDIPVAPFDVAAAQA
YGPVREAARERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T197008 NZ_CP095526:5111275-5111682 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9002.18 Da        Isoelectric Point: 7.0163

>AT197008 WP_096506786.1 NZ_CP071825:c3774510-3774274 [Burkholderia anthina]
MHTTKVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQALRKFAKFGPDFMAEGRGDQEQAEREGV

Download         Length: 237 bp

>AT197008 NZ_CP095526:5111028-5111294 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References