Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1867763..1868442 Replicon chromosome
Accession NZ_CP071825
Organism Burkholderia anthina strain 1CH1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag J4G50_RS08840 Protein ID WP_207998588.1
Coordinates 1867763..1868179 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag J4G50_RS08845 Protein ID WP_096505350.1
Coordinates 1868176..1868442 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G50_RS08815 1863605..1863904 - 300 WP_207998584.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4G50_RS08820 1863894..1864139 - 246 WP_207998585.1 type II toxin-antitoxin system ParD family antitoxin -
J4G50_RS08825 1864251..1865414 - 1164 WP_207998586.1 amidohydrolase -
J4G50_RS08830 1865774..1866844 + 1071 WP_207998678.1 hypothetical protein -
J4G50_RS08835 1866813..1867718 + 906 WP_207998587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
J4G50_RS08840 1867763..1868179 - 417 WP_207998588.1 PIN domain-containing protein Toxin
J4G50_RS08845 1868176..1868442 - 267 WP_096505350.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J4G50_RS08850 1868695..1869717 - 1023 WP_207998589.1 GNAT family N-acetyltransferase -
J4G50_RS08855 1869717..1870556 - 840 WP_207998590.1 N(5)-hydroxyornithine transformylase PvdF -
J4G50_RS08860 1870643..1872922 - 2280 WP_207998591.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14480.63 Da        Isoelectric Point: 8.5360

>T197007 WP_207998588.1 NZ_CP071825:c1868179-1867763 [Burkholderia anthina]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGKKASPKHAALVTAFVARLDGVLSWDTA
AVDATTAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFSRVAGLSVEDWAA

Download         Length: 417 bp

>T197007 NZ_CP095526:c4949126-4948749 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCAGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.08 Da        Isoelectric Point: 4.2917

>AT197007 WP_096505350.1 NZ_CP071825:c1868442-1868176 [Burkholderia anthina]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADSDFLVERPAVVETGRFDLSGTDD
DASTEASQ

Download         Length: 267 bp

>AT197007 NZ_CP095526:c4949550-4949173 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GTCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References