Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4730054..4730570 Replicon chromosome
Accession NZ_CP071819
Organism Klebsiella pneumoniae subsp. pneumoniae strain 90CM2

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IM758_RS23085 Protein ID WP_002886902.1
Coordinates 4730054..4730338 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IM758_RS23090 Protein ID WP_002886901.1
Coordinates 4730328..4730570 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM758_RS23060 (4725470) 4725470..4725733 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
IM758_RS23065 (4725863) 4725863..4726036 + 174 WP_032414892.1 hypothetical protein -
IM758_RS23070 (4726039) 4726039..4726782 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
IM758_RS23075 (4727139) 4727139..4729277 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IM758_RS23080 (4729586) 4729586..4730050 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IM758_RS23085 (4730054) 4730054..4730338 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM758_RS23090 (4730328) 4730328..4730570 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IM758_RS23095 (4730648) 4730648..4732558 - 1911 WP_009486549.1 PRD domain-containing protein -
IM758_RS23100 (4732581) 4732581..4733735 - 1155 WP_023302389.1 lactonase family protein -
IM758_RS23105 (4733802) 4733802..4734542 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T196994 WP_002886902.1 NZ_CP071819:c4730338-4730054 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T196994 NZ_CP095526:1847979-1848086 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT196994 WP_002886901.1 NZ_CP071819:c4730570-4730328 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT196994 NZ_CP095526:c1847926-1847865 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References