Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 822594..823251 Replicon chromosome
Accession NZ_CP071819
Organism Klebsiella pneumoniae subsp. pneumoniae strain 90CM2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IM758_RS04135 Protein ID WP_002916310.1
Coordinates 822841..823251 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IM758_RS04130 Protein ID WP_002916312.1
Coordinates 822594..822860 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM758_RS04105 (817750) 817750..819183 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IM758_RS04110 (819302) 819302..820030 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IM758_RS04115 (820080) 820080..820391 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IM758_RS04120 (820555) 820555..821214 + 660 WP_002916317.1 hemolysin III family protein -
IM758_RS04125 (821365) 821365..822348 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
IM758_RS04130 (822594) 822594..822860 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IM758_RS04135 (822841) 822841..823251 + 411 WP_002916310.1 protein YgfX Toxin
IM758_RS04140 (823258) 823258..823779 - 522 WP_004144730.1 flavodoxin FldB -
IM758_RS04145 (823880) 823880..824776 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IM758_RS04150 (824799) 824799..825512 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IM758_RS04155 (825518) 825518..827251 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T196982 WP_002916310.1 NZ_CP071819:822841-823251 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T196982 NZ_CP095520:c4286063-4285956 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT196982 WP_002916312.1 NZ_CP071819:822594-822860 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT196982 NZ_CP095520:4286120-4286177 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References