Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2386145..2387123 Replicon chromosome
Accession NZ_CP071811
Organism Bacillus mycoides strain JAS15/1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW36_RS12275 Protein ID WP_016126943.1
Coordinates 2386145..2386885 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW36_RS12280 Protein ID WP_000588712.1
Coordinates 2386998..2387123 (+) Length 42 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW36_RS12245 (EXW36_12245) 2381247..2382008 + 762 WP_002127420.1 ABC transporter ATP-binding protein -
EXW36_RS12250 (EXW36_12250) 2382114..2382824 + 711 WP_002127421.1 class I SAM-dependent methyltransferase -
EXW36_RS12255 (EXW36_12255) 2382943..2383356 + 414 WP_002012925.1 VOC family protein -
EXW36_RS12260 (EXW36_12260) 2383533..2384165 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW36_RS12265 (EXW36_12265) 2384439..2384915 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW36_RS12270 (EXW36_12270) 2385069..2385806 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW36_RS12275 (EXW36_12275) 2386145..2386885 + 741 WP_016126943.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW36_RS12280 (EXW36_12280) 2386998..2387123 + 126 WP_000588712.1 hypothetical protein Antitoxin
EXW36_RS12285 (EXW36_12285) 2387199..2387375 + 177 WP_003189253.1 stage II sporulation protein SB -
EXW36_RS12290 (EXW36_12290) 2387396..2387785 - 390 WP_016126944.1 YxeA family protein -
EXW36_RS12295 (EXW36_12295) 2388031..2389500 + 1470 WP_016126945.1 aminoacyl-histidine dipeptidase -
EXW36_RS12300 (EXW36_12300) 2389860..2390009 + 150 WP_002069316.1 hypothetical protein -
EXW36_RS12305 (EXW36_12305) 2390723..2391382 + 660 WP_003189261.1 CatB-related O-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-244)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 247 a.a.        Molecular weight: 28485.18 Da        Isoelectric Point: 8.3034

>T196975 WP_016126943.1 NZ_CP071811:2386145-2386885 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVESVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T196975 NZ_CP095520:2626316-2626690 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT196975 WP_000588712.1 NZ_CP071811:2386998-2387123 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT196975 NZ_CP095520:2625859-2626227 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References