Detailed information of TA system TA196970

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1522292..1523724
• Replicon: chromosome
• Accession: NZ_CP071806
• Organism: Streptococcus suis strain GX69

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A0Z8TB64
• Locus tag: JZ789_RS07565
• Protein ID: WP_024394846.1
• Coordinates: 1522879..1523724 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A0Z8SSH7
• Locus tag: JZ789_RS07560
• Protein ID: WP_002935109.1
• Coordinates: 1522292..1522882 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZ789_RS07535 (JZ789_07450)	1517411..1519560	-	2150	Protein_1450	peptide cleavage/export ABC transporter	-
JZ789_RS07540 (JZ789_07455)	1519763..1519954	-	192	WP_002935101.1	hypothetical protein	-
JZ789_RS07545 (JZ789_07460)	1520043..1520315	-	273	WP_002935103.1	DUF3884 family protein	-
JZ789_RS07550 (JZ789_07465)	1520344..1521660	-	1317	WP_002935107.1	glycosyltransferase family 2 protein	-
JZ789_RS07555 (JZ789_07470)	1521848..1522009	-	162	WP_002935108.1	agglutinin receptor	-
JZ789_RS07560 (JZ789_07475)	1522292..1522882	+	591	WP_002935109.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JZ789_RS07565 (JZ789_07480)	1522879..1523724	+	846	WP_024394846.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JZ789_RS07570 (JZ789_07485)	1523786..1526587	-	2802	WP_226315523.1	phage tail tip lysozyme	-
JZ789_RS07575 (JZ789_07490)	1526589..1527471	-	883	Protein_1458	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32466.18 Da
• Isoelectric Point: 5.4404

>T196970 WP_024394846.1 NZ_CP071806:1522879-1523724 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Nucleotide

• Length: 846 bp

>T196970 NZ_CP095520:c896730-896512 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23299.86 Da
• Isoelectric Point: 7.8482

>AT196970 WP_002935109.1 NZ_CP071806:1522292-1522882 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT196970 NZ_CP095520:c897130-896756 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A0Z8TB64

Antitoxin

• AlphaFold DB: A0A0Z8SSH7