Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 10210..10729 Replicon plasmid pYRKMM821_1
Accession NZ_CP071803
Organism Yersinia ruckeri strain KMM821

Toxin (Protein)


Gene name parE Uniprot ID A0A0A8VBJ3
Locus tag YR821_RS17135 Protein ID WP_038251372.1
Coordinates 10445..10729 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A380SA85
Locus tag YR821_RS17130 Protein ID WP_038251370.1
Coordinates 10210..10452 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YR821_RS17115 (YR821_p10008) 7038..7688 + 651 WP_040155137.1 recombinase family protein -
YR821_RS17120 (YR821_p10009) 7818..8087 - 270 WP_038251368.1 hypothetical protein -
YR821_RS17125 (YR821_p10010) 8183..8986 - 804 WP_004723260.1 replication initiation protein -
YR821_RS17130 (YR821_p10013) 10210..10452 + 243 WP_038251370.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
YR821_RS17135 (YR821_p10014) 10445..10729 + 285 WP_038251372.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YR821_RS17140 (YR821_p10015) 10934..11821 - 888 WP_049688246.1 hypothetical protein -
YR821_RS17145 (YR821_p10016) 11998..12168 + 171 WP_169309805.1 hypothetical protein -
YR821_RS17155 (YR821_p10018) 12619..13281 + 663 WP_038251374.1 hypothetical protein -
YR821_RS17160 13539..13703 - 165 WP_004723268.1 hypothetical protein -
YR821_RS17165 13730..13879 - 150 Protein_15 transcriptional regulator -
YR821_RS17170 (YR821_p10020) 14059..14700 + 642 WP_004723269.1 recombinase family protein -
YR821_RS17175 (YR821_p10021) 14956..15642 + 687 WP_004723270.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16925 16925
- flank IS/Tn - - 7038..7688 650
- flank IS/Tn - - 14059..14700 641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11019.55 Da        Isoelectric Point: 6.2111

>T196965 WP_038251372.1 NZ_CP071803:10445-10729 [Yersinia ruckeri]
VYKLTERAAEDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHAVPGVMRIEFQRHTIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T196965 NZ_CP095520:94901-95074 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8902.03 Da        Isoelectric Point: 7.0130

>AT196965 WP_038251370.1 NZ_CP071803:10210-10452 [Yersinia ruckeri]
MARTTSVTIGEQLDSFINRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT196965 NZ_CP095520:94577-94873 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8VBJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A380SA85

References