Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 3050786..3051486 Replicon chromosome
Accession NZ_CP071802
Organism Yersinia ruckeri strain KMM821

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A8VME3
Locus tag YR821_RS13990 Protein ID WP_004722495.1
Coordinates 3050786..3051142 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0A8VG75
Locus tag YR821_RS13995 Protein ID WP_038251171.1
Coordinates 3051154..3051486 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YR821_RS13955 (YR821_2896) 3046306..3046860 + 555 WP_004722507.1 hypothetical protein -
YR821_RS13960 (YR821_2897) 3046863..3047354 + 492 WP_230596550.1 hypothetical protein -
YR821_RS13965 (YR821_2899) 3047494..3047760 + 267 WP_038251173.1 hypothetical protein -
YR821_RS13970 (YR821_2900) 3048259..3049080 + 822 WP_038251172.1 DUF932 domain-containing protein -
YR821_RS13975 (YR821_2902) 3049442..3049873 + 432 WP_004722500.1 antirestriction protein -
YR821_RS13980 (YR821_2903) 3049906..3050379 + 474 WP_004722498.1 DNA repair protein RadC -
YR821_RS13985 3050373..3050705 + 333 WP_050777623.1 DUF5983 family protein -
YR821_RS13990 (YR821_2906) 3050786..3051142 + 357 WP_004722495.1 TA system toxin CbtA family protein Toxin
YR821_RS13995 (YR821_2907) 3051154..3051486 + 333 WP_038251171.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
YR821_RS14000 (YR821_2908) 3051571..3052437 + 867 WP_004722491.1 DUF4942 domain-containing protein -
YR821_RS14005 (YR821_2909) 3052622..3052945 + 324 WP_004722490.1 type II toxin-antitoxin system RelE/ParE family toxin -
YR821_RS14010 (YR821_2910) 3052932..3053219 + 288 WP_012104592.1 helix-turn-helix transcriptional regulator -
YR821_RS14015 (YR821_2911) 3053680..3053859 - 180 Protein_2726 tyrosine-type recombinase/integrase -
YR821_RS14020 (YR821_2912) 3054595..3055647 + 1053 WP_038240965.1 glycosyltransferase family 2 protein -
YR821_RS14025 (YR821_2913) 3055685..3056374 + 690 WP_004723367.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3042059..3059154 17095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12999.89 Da        Isoelectric Point: 6.4771

>T196964 WP_004722495.1 NZ_CP071802:3050786-3051142 [Yersinia ruckeri]
MKPRPTAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINALVEKYALVQIGRNGFSALAQ
DPMLSKGDIVRARQASGLWRAHFPPTLLYPTESLNPIP

Download         Length: 357 bp

>T196964 NZ_CP095519:c75311-75024 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12102.74 Da        Isoelectric Point: 7.3835

>AT196964 WP_038251171.1 NZ_CP071802:3051154-3051486 [Yersinia ruckeri]
MNNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQLLSGQLDPRRQQC
LTVRHGGFVCDADTLGSHGYVYIAVYQELS

Download         Length: 333 bp

>AT196964 NZ_CP095519:c75559-75308 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8VME3

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8VG75

References