Detailed information of TA system TA196954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1931586..1932504
• Replicon: chromosome
• Accession: NZ_CP071802
• Organism: Yersinia ruckeri strain KMM821

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: YR821_RS08625
• Protein ID: WP_038242633.1
• Coordinates: 1932046..1932504 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: YR821_RS08620
• Protein ID: WP_038242631.1
• Coordinates: 1931586..1932032 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YR821_RS08600 (YR821_1789)	1927284..1927988	+	705	WP_004717543.1	murein tripeptide amidase MpaA	-
YR821_RS08605 (YR821_1790)	1927999..1928973	-	975	WP_038251389.1	L-Ala-D/L-Glu epimerase	-
YR821_RS08610 (YR821_1791)	1929123..1929626	+	504	WP_004717547.1	thiol peroxidase	-
YR821_RS08615 (YR821_1792)	1929661..1931268	-	1608	WP_038251390.1	transcriptional regulator TyrR	-
YR821_RS08620 (YR821_1793)	1931586..1932032	+	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
YR821_RS08625 (YR821_1794)	1932046..1932504	+	459	WP_038242633.1	RES domain-containing protein	Toxin
YR821_RS08630 (YR821_1795)	1932508..1933566	-	1059	WP_038242635.1	YcjF family protein	-
YR821_RS08635 (YR821_1796)	1933563..1934960	-	1398	WP_004717556.1	YcjX family protein	-
YR821_RS08640 (YR821_1797)	1934941..1935183	-	243	WP_099511574.1	phage shock protein PspD	-
YR821_RS08645 (YR821_1798)	1935247..1935606	-	360	WP_004717559.1	envelope stress response membrane protein PspC	-
YR821_RS08650 (YR821_1799)	1935606..1935833	-	228	WP_038242637.1	envelope stress response membrane protein PspB	-
YR821_RS08655 (YR821_1800)	1935917..1936582	-	666	WP_004717561.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17072.55 Da
• Isoelectric Point: 6.6384

>T196954 WP_038242633.1 NZ_CP071802:1932046-1932504 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T196954 NZ_CP095518:3258299-3258706 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT196954 WP_038242631.1 NZ_CP071802:1931586-1932032 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT196954 NZ_CP095518:3258052-3258318 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3