Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 1062002..1062765 Replicon chromosome
Accession NZ_CP071802
Organism Yersinia ruckeri strain KMM821

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0A8VGU6
Locus tag YR821_RS04795 Protein ID WP_004720097.1
Coordinates 1062445..1062765 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A8VB89
Locus tag YR821_RS04790 Protein ID WP_004720095.1
Coordinates 1062002..1062370 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YR821_RS04750 (YR821_0974) 1057028..1057855 + 828 WP_004720076.1 hypothetical protein -
YR821_RS04755 (YR821_0975) 1057935..1058816 + 882 WP_230596577.1 50S ribosome-binding GTPase -
YR821_RS04760 (YR821_0976) 1059063..1059617 + 555 WP_004720086.1 hypothetical protein -
YR821_RS04765 (YR821_0977) 1059620..1060111 + 492 WP_004720088.1 hypothetical protein -
YR821_RS04770 (YR821_0978) 1060166..1060522 + 357 WP_004720091.1 hypothetical protein -
YR821_RS17680 (YR821_0979) 1060666..1060782 + 117 Protein_925 DUF945 domain-containing protein -
YR821_RS04775 (YR821_0980) 1060809..1061261 + 453 WP_004720092.1 antirestriction protein -
YR821_RS04780 (YR821_0981) 1061273..1061752 + 480 WP_004720093.1 DNA repair protein RadC -
YR821_RS04785 (YR821_0982) 1061756..1061968 + 213 WP_139127562.1 antirestriction protein -
YR821_RS04790 (YR821_0983) 1062002..1062370 + 369 WP_004720095.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
YR821_RS04795 (YR821_0984) 1062445..1062765 + 321 WP_004720097.1 TA system toxin CbtA family protein Toxin
YR821_RS04800 (YR821_0985) 1062883..1063716 + 834 WP_038251289.1 DUF4942 domain-containing protein -
YR821_RS04805 (YR821_0988) 1064640..1064990 + 351 WP_038251290.1 transcriptional regulator -
YR821_RS04810 (YR821_0989) 1065065..1066354 + 1290 WP_004720102.1 arsenic transporter -
YR821_RS04815 (YR821_0990) 1066367..1066792 + 426 WP_004720103.1 glutaredoxin-dependent arsenate reductase -
YR821_RS04820 (YR821_0991) 1067062..1067706 + 645 WP_038243845.1 thermostable hemolysin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12149.92 Da        Isoelectric Point: 6.0642

>T196953 WP_004720097.1 NZ_CP071802:1062445-1062765 [Yersinia ruckeri]
MQTLPVSPTREAQLGPSPAAVWKQLLTHLFEHHYGLTLNDTPFCYEFVIQEHIESGILLKDAVNFVVERYGLLRIDRSSF
SFDEPSPFINFTDILRARRAIGLMNT

Download         Length: 321 bp

>T196953 NZ_CP095518:c3167667-3167290 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTTCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATCGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13456.42 Da        Isoelectric Point: 6.9468

>AT196953 WP_004720095.1 NZ_CP071802:1062002-1062370 [Yersinia ruckeri]
MKPTPSKTIPPKDTTACLQWGLRHDITPCFGARLVQEGQRLHFLADRAGFCGVFSEEGARHLDQAFPLIMKQLELALLSG
ELDPRYQRSITLSHNGLTCEADALGSHGYVYITIYPTPSVTA

Download         Length: 369 bp

>AT196953 NZ_CP095518:c3168124-3167756 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
ACAGCAATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8VGU6

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8VB89

References