Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2334914..2335559 Replicon chromosome
Accession NZ_CP071798
Organism Sporosarcina sp. Te-1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag J3U78_RS11990 Protein ID WP_207958896.1
Coordinates 2334914..2335264 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag J3U78_RS11995 Protein ID WP_243458026.1
Coordinates 2335269..2335559 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3U78_RS11955 (J3U78_11955) 2330143..2330928 - 786 WP_184212239.1 RNA polymerase sigma factor SigB -
J3U78_RS11960 (J3U78_11960) 2330903..2331373 - 471 WP_207958890.1 anti-sigma B factor RsbW -
J3U78_RS11965 (J3U78_11965) 2331360..2331701 - 342 WP_207958891.1 anti-sigma factor antagonist -
J3U78_RS11970 (J3U78_11970) 2331773..2332786 - 1014 WP_207958892.1 PP2C family protein-serine/threonine phosphatase -
J3U78_RS11975 (J3U78_11975) 2332803..2333204 - 402 WP_207958893.1 anti-sigma regulatory factor -
J3U78_RS11980 (J3U78_11980) 2333207..2333569 - 363 WP_207958894.1 STAS domain-containing protein -
J3U78_RS11985 (J3U78_11985) 2333566..2334396 - 831 WP_207958895.1 RsbT co-antagonist protein RsbRA -
J3U78_RS11990 (J3U78_11990) 2334914..2335264 - 351 WP_207958896.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J3U78_RS11995 (J3U78_11995) 2335269..2335559 - 291 WP_243458026.1 transcriptional regulator Antitoxin
J3U78_RS12000 (J3U78_12000) 2335720..2336832 - 1113 WP_207958897.1 alanine racemase -
J3U78_RS12005 (J3U78_12005) 2336934..2337944 - 1011 WP_207958898.1 outer-membrane lipoprotein carrier protein LolA -
J3U78_RS12010 (J3U78_12010) 2338076..2338429 - 354 WP_207958899.1 holo-ACP synthase -
J3U78_RS12015 (J3U78_12015) 2338498..2339088 + 591 WP_207958900.1 rhomboid family intramembrane serine protease -
J3U78_RS12020 (J3U78_12020) 2339130..2339276 + 147 WP_207958901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12966.90 Da        Isoelectric Point: 4.9105

>T196951 WP_207958896.1 NZ_CP071798:c2335264-2334914 [Sporosarcina sp. Te-1]
MAIKRGDVFFADLSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAERYGFERDSVILLEQV
RTIDKSRLTDKITHLDEQLMERVDEALEVSFGLIKF

Download         Length: 351 bp

>T196951 NZ_CP095518:c1953206-1953099 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11310.19 Da        Isoelectric Point: 6.6438

>AT196951 WP_243458026.1 NZ_CP071798:c2335559-2335269 [Sporosarcina sp. Te-1]
VLVLREKKNIKEVIVKIPKRMLTEIEHTVVHQEPEREEFVYVSTKRYVTDYEAETIREVMMKGYVEMSHINLKIAKECLH
AELEAQHTMERLVSGG

Download         Length: 291 bp

>AT196951 NZ_CP095518:1953263-1953320 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References