Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1739251..1739872 Replicon chromosome
Accession NZ_CP071797
Organism Pseudomonas fluorescens strain YK-310

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JZM58_RS07855 Protein ID WP_007957952.1
Coordinates 1739693..1739872 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JZM58_RS07850 Protein ID WP_207985297.1
Coordinates 1739251..1739658 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZM58_RS07825 (JZM58_07825) 1734708..1735118 - 411 WP_007957945.1 low affinity iron permease family protein -
JZM58_RS07830 (JZM58_07830) 1735345..1736430 + 1086 WP_207985293.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
JZM58_RS07835 (JZM58_07835) 1736592..1737362 + 771 WP_207985294.1 trans-aconitate 2-methyltransferase -
JZM58_RS07840 (JZM58_07840) 1737403..1738131 - 729 WP_207985295.1 class I SAM-dependent methyltransferase -
JZM58_RS07845 (JZM58_07845) 1738661..1739029 + 369 WP_207985296.1 DUF6124 family protein -
JZM58_RS07850 (JZM58_07850) 1739251..1739658 - 408 WP_207985297.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JZM58_RS07855 (JZM58_07855) 1739693..1739872 - 180 WP_007957952.1 type II toxin-antitoxin system HicA family toxin Toxin
JZM58_RS07860 (JZM58_07860) 1740095..1740505 - 411 WP_207985298.1 PaaI family thioesterase -
JZM58_RS07870 (JZM58_07870) 1741032..1741916 - 885 WP_207985299.1 alpha/beta hydrolase -
JZM58_RS07875 (JZM58_07875) 1742232..1742924 - 693 WP_207985300.1 pseudouridine synthase -
JZM58_RS07880 (JZM58_07880) 1742958..1743176 - 219 WP_192560013.1 cysteine-rich CWC family protein -
JZM58_RS07885 (JZM58_07885) 1743182..1744669 - 1488 WP_207985301.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6660.91 Da        Isoelectric Point: 11.4113

>T196945 WP_007957952.1 NZ_CP071797:c1739872-1739693 [Pseudomonas fluorescens]
VNSRFLIGQLVADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Download         Length: 180 bp

>T196945 NZ_CP095518:c1177296-1176982 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14617.63 Da        Isoelectric Point: 4.7269

>AT196945 WP_207985297.1 NZ_CP071797:c1739658-1739251 [Pseudomonas fluorescens]
MLYPIAISVGDEGHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGSPIPSANKVTLHAANPKYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQR

Download         Length: 408 bp

>AT196945 NZ_CP095518:c1177532-1177299 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References