Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 572142..572781 Replicon chromosome
Accession NZ_CP071797
Organism Pseudomonas fluorescens strain YK-310

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JZM58_RS02545 Protein ID WP_207984729.1
Coordinates 572142..572324 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JZM58_RS02550 Protein ID WP_207984730.1
Coordinates 572356..572781 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZM58_RS02505 (JZM58_02505) 567149..567526 + 378 WP_096821986.1 GNAT family N-acetyltransferase -
JZM58_RS02510 (JZM58_02510) 567523..568239 + 717 WP_085702720.1 AzlC family ABC transporter permease -
JZM58_RS02515 (JZM58_02515) 568218..568535 + 318 WP_007952614.1 AzlD domain-containing protein -
JZM58_RS02520 (JZM58_02520) 568452..569378 - 927 WP_207984725.1 LysR family transcriptional regulator -
JZM58_RS02525 (JZM58_02525) 569757..569975 + 219 WP_207984726.1 4-oxalocrotonate tautomerase family protein -
JZM58_RS02530 (JZM58_02530) 569972..570616 + 645 WP_207984727.1 DsbA family oxidoreductase -
JZM58_RS02535 (JZM58_02535) 570650..571360 + 711 WP_207984728.1 SDR family NAD(P)-dependent oxidoreductase -
JZM58_RS02540 (JZM58_02540) 571419..571685 - 267 WP_085698038.1 DUF3077 domain-containing protein -
JZM58_RS02545 (JZM58_02545) 572142..572324 + 183 WP_207984729.1 type II toxin-antitoxin system HicA family toxin Toxin
JZM58_RS02550 (JZM58_02550) 572356..572781 + 426 WP_207984730.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JZM58_RS02555 (JZM58_02555) 573014..573235 + 222 Protein_502 tyrosine-type recombinase/integrase -
JZM58_RS02560 (JZM58_02560) 573232..573822 + 591 WP_207984731.1 hypothetical protein -
JZM58_RS29135 573905..574027 + 123 Protein_504 transcriptional regulator -
JZM58_RS02565 (JZM58_02565) 574380..575804 + 1425 WP_207984732.1 tyrosine-type recombinase/integrase -
JZM58_RS02570 (JZM58_02570) 577123..577290 + 168 WP_192559520.1 hypothetical protein -
JZM58_RS02575 (JZM58_02575) 577292..577591 + 300 WP_207984733.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6734.79 Da        Isoelectric Point: 10.7304

>T196944 WP_207984729.1 NZ_CP071797:572142-572324 [Pseudomonas fluorescens]
MKYSEFRRWLKAQGVEFQAGKGSHFKVSLNGKSTVFPDHGAKEIGEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T196944 NZ_CP095518:753692-753910 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15502.55 Da        Isoelectric Point: 4.3686

>AT196944 WP_207984730.1 NZ_CP071797:572356-572781 [Pseudomonas fluorescens]
MFEYALEVHEEPSSVWLSCAEIPEMHAAGDTLEEALDGAIDAMETALSIYVDDRRLIPTGDAGEQESDAVLRLPALTAAK
VGLWNSLLESGVSKAELARRLGVQRPQVDRLVDFLHHSKIENVERALQQLGRRILLSVEAA

Download         Length: 426 bp

>AT196944 NZ_CP095518:753292-753666 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References