Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 423466..423982 Replicon chromosome
Accession NZ_CP071797
Organism Pseudomonas fluorescens strain YK-310

Toxin (Protein)


Gene name relE Uniprot ID A0A0C1WG29
Locus tag JZM58_RS01845 Protein ID WP_039773012.1
Coordinates 423701..423982 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C1VYZ2
Locus tag JZM58_RS01840 Protein ID WP_039773014.1
Coordinates 423466..423711 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZM58_RS01805 (JZM58_01805) 418803..419408 + 606 WP_207984632.1 adenylyl-sulfate kinase -
JZM58_RS01810 (JZM58_01810) 419405..420190 + 786 WP_207984634.1 aspartyl/asparaginyl beta-hydroxylase domain-containing protein -
JZM58_RS01815 (JZM58_01815) 420178..421152 + 975 WP_207984636.1 sulfotransferase family protein -
JZM58_RS01820 (JZM58_01820) 421118..421876 - 759 WP_007957673.1 slipin family protein -
JZM58_RS01825 (JZM58_01825) 421879..422406 - 528 WP_207984638.1 NfeD family protein -
JZM58_RS01830 (JZM58_01830) 422602..423063 + 462 WP_207984640.1 YbaK/EbsC family protein -
JZM58_RS01835 (JZM58_01835) 423128..423370 + 243 WP_207984642.1 DUF2789 domain-containing protein -
JZM58_RS01840 (JZM58_01840) 423466..423711 + 246 WP_039773014.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JZM58_RS01845 (JZM58_01845) 423701..423982 + 282 WP_039773012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZM58_RS01850 (JZM58_01850) 424107..424535 + 429 WP_011331882.1 winged helix DNA-binding protein -
JZM58_RS01855 (JZM58_01855) 424532..426595 + 2064 WP_207984644.1 FUSC family protein -
JZM58_RS01860 (JZM58_01860) 426592..426801 + 210 WP_007957657.1 DUF1656 domain-containing protein -
JZM58_RS01865 (JZM58_01865) 426798..427685 + 888 WP_085684315.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10971.80 Da        Isoelectric Point: 10.4588

>T196943 WP_039773012.1 NZ_CP071797:423701-423982 [Pseudomonas fluorescens]
MTYKLEFLPSAHKEWNKLGHTLRDQFKKKLAERLERPRIPADSLHGMPDCYKIKLKASGYRLVYQVIEERVVVSVVAVGK
RERSDVYENAKRR

Download         Length: 282 bp

>T196943 NZ_CP095518:c98513-98133 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8776.06 Da        Isoelectric Point: 4.4988

>AT196943 WP_039773014.1 NZ_CP071797:423466-423711 [Pseudomonas fluorescens]
MQSVLADMAVSVSELKKNPSAVLNGAHGGAVAVLNHNRVMGYMVPADVYEAMMERLDDLELAEIVRSRSHETPIPVSLDD
L

Download         Length: 246 bp

>AT196943 NZ_CP095518:c98934-98560 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1WG29

Antitoxin

Source ID Structure
AlphaFold DB A0A0C1VYZ2

References