Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 3861496..3862196 Replicon chromosome
Accession NZ_CP071796
Organism Ottowia testudinis strain 27C

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J1M35_RS18285 Protein ID WP_208008724.1
Coordinates 3861756..3862196 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J1M35_RS18280 Protein ID WP_208008723.1
Coordinates 3861496..3861747 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1M35_RS18270 (J1M35_18270) 3856979..3857386 - 408 WP_208008721.1 hypothetical protein -
J1M35_RS18275 (J1M35_18275) 3857408..3861400 - 3993 WP_208008722.1 tape measure protein -
J1M35_RS18280 (J1M35_18280) 3861496..3861747 + 252 WP_208008723.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J1M35_RS18285 (J1M35_18285) 3861756..3862196 + 441 WP_208008724.1 type II toxin-antitoxin system VapC family toxin Toxin
J1M35_RS18290 (J1M35_18290) 3862173..3862832 - 660 WP_208008725.1 DUF6441 family protein -
J1M35_RS18295 (J1M35_18295) 3862845..3862985 - 141 WP_208008726.1 hypothetical protein -
J1M35_RS18300 (J1M35_18300) 3863042..3863497 - 456 WP_208008727.1 hypothetical protein -
J1M35_RS18305 (J1M35_18305) 3863509..3864312 - 804 WP_208008728.1 hypothetical protein -
J1M35_RS18310 (J1M35_18310) 3864309..3864572 - 264 WP_243457501.1 hypothetical protein -
J1M35_RS18315 (J1M35_18315) 3864625..3865110 - 486 WP_208008729.1 hypothetical protein -
J1M35_RS18320 (J1M35_18320) 3865113..3865502 - 390 WP_243457502.1 hypothetical protein -
J1M35_RS18325 (J1M35_18325) 3865516..3866517 - 1002 WP_208011544.1 major capsid protein -
J1M35_RS18330 (J1M35_18330) 3866544..3866921 - 378 WP_208008730.1 head decoration protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3857408..3891708 34300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-63)


Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16412.97 Da        Isoelectric Point: 9.6210

>T196942 WP_208008724.1 NZ_CP071796:3861756-3862196 [Ottowia testudinis]
MRYLIDTNVLSELRKKQPDANVVAWMKERPRQSLFLSVLTLGEIRKGVEQLPDSARKLSLLDWLTVELPNYFVGRLLPVD
ADVADQWGHLSAKAGRPLPAVDALLAATALQHRLTLVTRNTRDFEGLGVDLLNPWETHSSPPQPKK

Download         Length: 441 bp

>T196942 NZ_CP095517:41640-41789 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9495.70 Da        Isoelectric Point: 5.0175

>AT196942 WP_208008723.1 NZ_CP071796:3861496-3861747 [Ottowia testudinis]
MQTWQMQTAKAQFSDLVQRAKSDGPQEITVHGRSVAVVMSREMFDRLSGNQDSLVDFMRQSPLYGLEDIRIERDCSPGRD
ISF

Download         Length: 252 bp

>AT196942 NZ_CP095517:c41592-41536 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References