Detailed information of TA system TA196938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2074834..2075492
• Replicon: chromosome
• Accession: NZ_CP071796
• Organism: Ottowia testudinis strain 27C

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J1M35_RS09775
• Protein ID: WP_208011019.1
• Coordinates: 2074834..2075229 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J1M35_RS09780
• Protein ID: WP_208011020.1
• Coordinates: 2075229..2075492 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1M35_RS09760 (J1M35_09760)	2070577..2072688	+	2112	WP_208011017.1	3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein	-
J1M35_RS09765 (J1M35_09765)	2072747..2073922	+	1176	WP_208011018.1	acetyl-CoA C-acyltransferase	-
J1M35_RS09775 (J1M35_09775)	2074834..2075229	-	396	WP_208011019.1	type II toxin-antitoxin system VapC family toxin	Toxin
J1M35_RS09780 (J1M35_09780)	2075229..2075492	-	264	WP_208011020.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
J1M35_RS09785 (J1M35_09785)	2075596..2075898	-	303	WP_208011021.1	DUF6506 family protein	-
J1M35_RS09790 (J1M35_09790)	2076010..2076924	+	915	WP_208011022.1	LysR family transcriptional regulator	-
J1M35_RS09795 (J1M35_09795)	2076995..2078830	+	1836	WP_208011023.1	acyl-CoA dehydrogenase	-
J1M35_RS09800 (J1M35_09800)	2078856..2079647	+	792	WP_208011024.1	SDR family oxidoreductase	-
J1M35_RS09805 (J1M35_09805)	2079676..2080443	+	768	WP_208011025.1	YoaP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

• SpoVT-AbrB domain (8-55)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14769.01 Da
• Isoelectric Point: 8.1664

>T196938 WP_208011019.1 NZ_CP071796:c2075229-2074834 [Ottowia testudinis]
MRYMLGTNVVSHLVRAHPSVSRRVASMPAGHLCISAVTEAELRYGLEKHRGAHRLQSLIYEFLASIPIMPWRHEEAIVYA
QFRNSLERQGRSLAAHDALIAAHAKSLGLILVSNDQAFVNLVDMPFEDWTH

Nucleotide

• Length: 396 bp

>T196938 NZ_CP095514:c4878056-4877949 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10173.39 Da
• Isoelectric Point: 4.6812

>AT196938 WP_208011020.1 NZ_CP071796:c2075492-2075229 [Ottowia testudinis]
MMQTAKLFTNGRSQAVRLPREFRFEETEVYIRRDASTGDVILSRKPASLDRFFELLREGVDVPQDFLSPDERHVADDLRD
PFAGWQE

Nucleotide

• Length: 264 bp

>AT196938 NZ_CP095514:4878104-4878170 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT