Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2074834..2075492 Replicon chromosome
Accession NZ_CP071796
Organism Ottowia testudinis strain 27C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J1M35_RS09775 Protein ID WP_208011019.1
Coordinates 2074834..2075229 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J1M35_RS09780 Protein ID WP_208011020.1
Coordinates 2075229..2075492 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1M35_RS09760 (J1M35_09760) 2070577..2072688 + 2112 WP_208011017.1 3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein -
J1M35_RS09765 (J1M35_09765) 2072747..2073922 + 1176 WP_208011018.1 acetyl-CoA C-acyltransferase -
J1M35_RS09775 (J1M35_09775) 2074834..2075229 - 396 WP_208011019.1 type II toxin-antitoxin system VapC family toxin Toxin
J1M35_RS09780 (J1M35_09780) 2075229..2075492 - 264 WP_208011020.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J1M35_RS09785 (J1M35_09785) 2075596..2075898 - 303 WP_208011021.1 DUF6506 family protein -
J1M35_RS09790 (J1M35_09790) 2076010..2076924 + 915 WP_208011022.1 LysR family transcriptional regulator -
J1M35_RS09795 (J1M35_09795) 2076995..2078830 + 1836 WP_208011023.1 acyl-CoA dehydrogenase -
J1M35_RS09800 (J1M35_09800) 2078856..2079647 + 792 WP_208011024.1 SDR family oxidoreductase -
J1M35_RS09805 (J1M35_09805) 2079676..2080443 + 768 WP_208011025.1 YoaP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(8-55)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14769.01 Da        Isoelectric Point: 8.1664

>T196938 WP_208011019.1 NZ_CP071796:c2075229-2074834 [Ottowia testudinis]
MRYMLGTNVVSHLVRAHPSVSRRVASMPAGHLCISAVTEAELRYGLEKHRGAHRLQSLIYEFLASIPIMPWRHEEAIVYA
QFRNSLERQGRSLAAHDALIAAHAKSLGLILVSNDQAFVNLVDMPFEDWTH

Download         Length: 396 bp

>T196938 NZ_CP095514:c4878056-4877949 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10173.39 Da        Isoelectric Point: 4.6812

>AT196938 WP_208011020.1 NZ_CP071796:c2075492-2075229 [Ottowia testudinis]
MMQTAKLFTNGRSQAVRLPREFRFEETEVYIRRDASTGDVILSRKPASLDRFFELLREGVDVPQDFLSPDERHVADDLRD
PFAGWQE

Download         Length: 264 bp

>AT196938 NZ_CP095514:4878104-4878170 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References