Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2045045..2045709 Replicon chromosome
Accession NZ_CP071796
Organism Ottowia testudinis strain 27C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J1M35_RS09640 Protein ID WP_208010993.1
Coordinates 2045269..2045709 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J1M35_RS09635 Protein ID WP_208010992.1
Coordinates 2045045..2045272 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1M35_RS09620 (J1M35_09620) 2040339..2043029 - 2691 WP_208010989.1 [protein-PII] uridylyltransferase -
J1M35_RS09625 (J1M35_09625) 2043042..2043860 - 819 WP_208010990.1 type I methionyl aminopeptidase -
J1M35_RS09630 (J1M35_09630) 2043990..2045000 + 1011 WP_208010991.1 class I SAM-dependent methyltransferase -
J1M35_RS09635 (J1M35_09635) 2045045..2045272 + 228 WP_208010992.1 hypothetical protein Antitoxin
J1M35_RS09640 (J1M35_09640) 2045269..2045709 + 441 WP_208010993.1 PIN domain-containing protein Toxin
J1M35_RS09645 (J1M35_09645) 2045746..2047518 + 1773 Protein_1917 phosphoribosylformylglycinamidine synthase -
J1M35_RS09650 (J1M35_09650) 2047560..2047955 + 396 WP_208010995.1 hypothetical protein -
J1M35_RS09655 (J1M35_09655) 2048000..2048656 - 657 WP_208010996.1 amino acid ABC transporter permease -
J1M35_RS09660 (J1M35_09660) 2048653..2049336 - 684 WP_208010997.1 amino acid ABC transporter permease -
J1M35_RS09665 (J1M35_09665) 2049430..2050212 - 783 WP_208010998.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(4-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 15947.42 Da        Isoelectric Point: 7.8472

>T196937 WP_208010993.1 NZ_CP071796:2045269-2045709 [Ottowia testudinis]
MSGALLDANALIALCWPQHEHHARIHRWFAAHAAQGWATCAFTQAAFLRIVSQPSFAGRAVPMADVAASLMHSIAHPQHR
YLAATPDLAAVLATCTGGVLGHRQVTDAWLLTAAVQHQMKLLTFDKAVYTLLATDAERQRCVWMPD

Download         Length: 441 bp

>T196937 NZ_CP095514:4450492-4450956 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8075.23 Da        Isoelectric Point: 7.0065

>AT196937 WP_208010992.1 NZ_CP071796:2045045-2045272 [Ottowia testudinis]
MRTTITLESDAFAAAQAYAQARALKLGQAVSELIRQASTQRLPLVQKNGVWVFDLPADTPPVTAAHVKSLLDDTP

Download         Length: 228 bp

>AT196937 NZ_CP095514:4450157-4450492 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References