Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1733776..1734429 Replicon chromosome
Accession NZ_CP071796
Organism Ottowia testudinis strain 27C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J1M35_RS08145 Protein ID WP_208010728.1
Coordinates 1734022..1734429 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J1M35_RS08140 Protein ID WP_208010727.1
Coordinates 1733776..1734009 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1M35_RS08115 (J1M35_08115) 1729296..1730303 + 1008 WP_208010722.1 iron ABC transporter permease -
J1M35_RS08120 (J1M35_08120) 1730300..1731091 + 792 WP_208010723.1 ABC transporter ATP-binding protein -
J1M35_RS08125 (J1M35_08125) 1731088..1731921 + 834 WP_208010724.1 precorrin-4 C(11)-methyltransferase -
J1M35_RS08130 (J1M35_08130) 1731918..1732838 + 921 WP_208010725.1 sirohydrochlorin chelatase -
J1M35_RS08135 (J1M35_08135) 1733042..1733728 + 687 WP_208010726.1 precorrin-8X methylmutase -
J1M35_RS08140 (J1M35_08140) 1733776..1734009 + 234 WP_208010727.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J1M35_RS08145 (J1M35_08145) 1734022..1734429 + 408 WP_208010728.1 type II toxin-antitoxin system VapC family toxin Toxin
J1M35_RS08150 (J1M35_08150) 1734504..1734932 - 429 WP_208010729.1 putative toxin-antitoxin system toxin component, PIN family -
J1M35_RS08155 (J1M35_08155) 1734925..1735191 - 267 WP_208010730.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
J1M35_RS08160 (J1M35_08160) 1735244..1736452 + 1209 WP_208010731.1 cobalt-precorrin-5B (C(1))-methyltransferase -
J1M35_RS08165 (J1M35_08165) 1736449..1737768 + 1320 WP_208010732.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
J1M35_RS08170 (J1M35_08170) 1737765..1738556 + 792 WP_208010733.1 precorrin-2 C(20)-methyltransferase -
J1M35_RS08175 (J1M35_08175) 1738553..1739356 + 804 WP_208010734.1 cobalamin biosynthesis central domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15254.63 Da        Isoelectric Point: 7.9669

>T196936 WP_208010728.1 NZ_CP071796:1734022-1734429 [Ottowia testudinis]
MLRYMLDTNIVIYVMKRRPLAALEVFNRHAGAMCISSITLSELCHGAEKSERREHSLRHVESFVSRLEVLPYGAKAAMHY
GSIRAMLERQGQIIGENDLHIAAHARSEGLTLVSNNLREFERVPGLLLENWVGQG

Download         Length: 408 bp

>T196936 NZ_CP095514:4241708-4242085 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8739.93 Da        Isoelectric Point: 6.2139

>AT196936 WP_208010727.1 NZ_CP071796:1733776-1734009 [Ottowia testudinis]
MTQAAVFMNNRSQAVRLPAEMRFADHVKKVHVRVVGAERILAPADQVWDSFFLSQEGVDEDFMAERAVQHPSTREAL

Download         Length: 234 bp

>AT196936 NZ_CP095514:4241251-4241631 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References