Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1442999..1444593 Replicon chromosome
Accession NZ_CP071794
Organism Parasphingorhabdus cellanae strain JHSY0214

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag J4G78_RS07090 Protein ID WP_207989645.1
Coordinates 1443250..1444593 (+) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag J4G78_RS07085 Protein ID WP_207989643.1
Coordinates 1442999..1443250 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G78_RS07055 (J4G78_07055) 1438165..1439379 - 1215 WP_207989638.1 replication initiation protein RepC -
J4G78_RS07065 (J4G78_07065) 1439827..1441047 + 1221 WP_207989639.1 tyrosine-type recombinase/integrase -
J4G78_RS07070 (J4G78_07070) 1441051..1441278 - 228 WP_207989640.1 helix-turn-helix domain-containing protein -
J4G78_RS07075 (J4G78_07075) 1441436..1441708 - 273 WP_207989641.1 HU family DNA-binding protein -
J4G78_RS07080 (J4G78_07080) 1441985..1442614 + 630 WP_207989642.1 helix-turn-helix transcriptional regulator -
J4G78_RS07085 (J4G78_07085) 1442999..1443250 + 252 WP_207989643.1 helix-turn-helix domain-containing protein Antitoxin
J4G78_RS07090 (J4G78_07090) 1443250..1444593 + 1344 WP_207989645.1 type II toxin-antitoxin system HipA family toxin Toxin
J4G78_RS07100 (J4G78_07100) 1445058..1445480 - 423 WP_243457263.1 cupin domain-containing protein -
J4G78_RS07105 (J4G78_07105) 1445611..1445817 - 207 WP_207990518.1 helix-turn-helix transcriptional regulator -
J4G78_RS07110 (J4G78_07110) 1445814..1446212 - 399 WP_207990879.1 hypothetical protein -
J4G78_RS07115 (J4G78_07115) 1446285..1447682 - 1398 WP_207989647.1 hypothetical protein -
J4G78_RS07120 (J4G78_07120) 1447734..1448414 - 681 WP_207989649.1 RES family NAD+ phosphorylase -
J4G78_RS07125 (J4G78_07125) 1448411..1448803 - 393 WP_207989651.1 DUF2384 domain-containing protein -
J4G78_RS07130 (J4G78_07130) 1449002..1449307 - 306 WP_207989652.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(154-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49931.99 Da        Isoelectric Point: 6.5686

>T196931 WP_207989645.1 NZ_CP071794:1443250-1444593 [Parasphingorhabdus cellanae]
MARRKTHEPLNVLINNRLAGRLEKQTDGAIRFTYDRMWLDWEHRFPISLSLPLLPTKFRGEQVVAVFDNLLPDSDKVRQR
VAERTGAQGTDSYSLLERIGRDCVGAMQFLPDGVDHDARAKVEGEPINELEIEAMLANLEAAPLGIDEDHEFRISVAGAQ
EKTALLRQEGQWKRPIGTTPTTHILKPQIGEIPSASGMIDMTNSVENEHYCLKLMEGFGLDVAQTEVATFGARKVLVVER
FDRQWQDDGRLIRLPQEDCCQALGIPSSRKYQSTVQGGENGPSTVDILDLLQSSDDPLKDQADFFKSQIIFWLISATDGH
GKNFSIFLKPGGGFALTPFYDVLSAQPVFDKKQIAHNKYKLAMSVGRSRKYKILDVHGRHFVETAKEAGLGPTLISKTLD
EIIEHAPIALDYALAGMPKAFHTNIHKSISKAIKDRMSQLKTAFAEI

Download         Length: 1344 bp

>T196931 NZ_CP095514:3050948-3051322 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9090.62 Da        Isoelectric Point: 11.2210

>AT196931 WP_207989643.1 NZ_CP071794:1442999-1443250 [Parasphingorhabdus cellanae]
MSQMARSPKQLGVAIQQQRFKRAMSQSELAKLTGTSQKTISKVENGNPATKIETVFALMAALDMQMTLLSRSKTASKNIG
DIF

Download         Length: 252 bp

>AT196931 NZ_CP095514:3050491-3050859 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References