Detailed information of TA system TA196928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 5299901..5300550
• Replicon: chromosome
• Accession: NZ_CP071793
• Organism: Sulfidibacter corallicola strain M133

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: J3U87_RS15875
• Protein ID: WP_237384035.1
• Coordinates: 5299901..5300326 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: J3U87_RS15880
• Protein ID: WP_237384036.1
• Coordinates: 5300323..5300550 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3U87_RS15865 (J3U87_15905)	5297673..5298584	+	912	WP_237384033.1	hypothetical protein	-
J3U87_RS15870 (J3U87_15910)	5298847..5299632	-	786	WP_237384034.1	cyclic nucleotide-binding domain-containing protein	-
J3U87_RS15875 (J3U87_15915)	5299901..5300326	-	426	WP_237384035.1	type II toxin-antitoxin system VapC family toxin	Toxin
J3U87_RS15880 (J3U87_15920)	5300323..5300550	-	228	WP_237384036.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
J3U87_RS15885 (J3U87_15925)	5300912..5301574	+	663	WP_237384037.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
J3U87_RS15890 (J3U87_15930)	5302029..5302727	+	699	WP_237384038.1	hypothetical protein	-
J3U87_RS15895 (J3U87_15935)	5302769..5304895	-	2127	WP_237384039.1	SpoIIE family protein phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-121)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15770.26 Da
• Isoelectric Point: 6.2336

>T196928 WP_237384035.1 NZ_CP071793:c5300326-5299901 [Sulfidibacter corallicola]
MTRLIMLDTNTCSFIMRKRPPTILETMTRYVLEGNLLVISAITYLELRYGAIGKKASPKHNLLVTEFVDRIDEVVGFDRE
AVESTARLKKHLSDRGTPICPNDTLIAGHALAIDAVLVTDNLAEFGRVPDLELENWKTGSQ

Nucleotide

• Length: 426 bp

>T196928 NZ_CP095514:c2401320-2401042 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8779.07 Da
• Isoelectric Point: 6.3547

>AT196928 WP_237384036.1 NZ_CP071793:c5300550-5300323 [Sulfidibacter corallicola]
MKTARLFKNGQNQAVRLPREMEFKGVREVEIRREGRSLVLTPVKKDWMSFGELPAADDDFLADRPSILEEDRIQF

Nucleotide

• Length: 228 bp

>AT196928 NZ_CP095514:c2401042-2400758 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA