Detailed information of TA system TA196922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3827687..3828298
• Replicon: chromosome
• Accession: NZ_CP071780
• Organism: Proteus mirabilis strain swupm3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: J3U94_RS17485
• Protein ID: WP_020946503.1
• Coordinates: 3827687..3828040 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: J3U94_RS17490
• Protein ID: WP_004249771.1
• Coordinates: 3828041..3828298 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3U94_RS17465 (J3U94_17440)	3822920..3823723	+	804	WP_004249775.1	energy transducer TonB	-
J3U94_RS17470 (J3U94_17445)	3823777..3825738	-	1962	WP_004249774.1	insecticidal delta-endotoxin Cry8Ea1 family protein	-
J3U94_RS17475 (J3U94_17450)	3825770..3826699	-	930	WP_004246518.1	metallophosphoesterase	-
J3U94_RS17480 (J3U94_17455)	3826884..3827348	-	465	WP_012368636.1	DUF1097 domain-containing protein	-
J3U94_RS17485 (J3U94_17460)	3827687..3828040	-	354	WP_020946503.1	HipA N-terminal domain-containing protein	Toxin
J3U94_RS17490 (J3U94_17465)	3828041..3828298	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
J3U94_RS17495 (J3U94_17470)	3828447..3829811	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
J3U94_RS17500 (J3U94_17475)	3829949..3831589	-	1641	WP_004246512.1	membrane protein insertase YidC	-
J3U94_RS17505 (J3U94_17480)	3831592..3831852	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
J3U94_RS17510 (J3U94_17485)	3831816..3832175	-	360	WP_004246510.1	ribonuclease P protein component	-
J3U94_RS17515 (J3U94_17490)	3832193..3832336	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13146.76 Da
• Isoelectric Point: 4.5238

>T196922 WP_020946503.1 NZ_CP071780:c3828040-3827687 [Proteus mirabilis]
MASLDVYMNEYYMGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIE

Nucleotide

• Length: 354 bp

>T196922 NZ_CP095514:817030-817317 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT196922 WP_004249771.1 NZ_CP071780:c3828298-3828041 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT196922 NZ_CP095514:817304-817606 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: B4F0T9