Detailed information of TA system TA196917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3827670..3828281
• Replicon: chromosome
• Accession: NZ_CP071777
• Organism: Proteus mirabilis strain swupm2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: J3U93_RS17475
• Protein ID: WP_020946503.1
• Coordinates: 3827670..3828023 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: J3U93_RS17480
• Protein ID: WP_004249771.1
• Coordinates: 3828024..3828281 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3U93_RS17455 (J3U93_17430)	3822903..3823706	+	804	WP_004249775.1	energy transducer TonB	-
J3U93_RS17460 (J3U93_17435)	3823760..3825721	-	1962	WP_004249774.1	insecticidal delta-endotoxin Cry8Ea1 family protein	-
J3U93_RS17465 (J3U93_17440)	3825753..3826682	-	930	WP_004246518.1	metallophosphoesterase	-
J3U93_RS17470 (J3U93_17445)	3826867..3827331	-	465	WP_012368636.1	DUF1097 domain-containing protein	-
J3U93_RS17475 (J3U93_17450)	3827670..3828023	-	354	WP_020946503.1	HipA N-terminal domain-containing protein	Toxin
J3U93_RS17480 (J3U93_17455)	3828024..3828281	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
J3U93_RS17485 (J3U93_17460)	3828430..3829794	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
J3U93_RS17490 (J3U93_17465)	3829932..3831572	-	1641	WP_004246512.1	membrane protein insertase YidC	-
J3U93_RS17495 (J3U93_17470)	3831575..3831835	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
J3U93_RS17500 (J3U93_17475)	3831799..3832158	-	360	WP_004246510.1	ribonuclease P protein component	-
J3U93_RS17505 (J3U93_17480)	3832176..3832319	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13146.76 Da
• Isoelectric Point: 4.5238

>T196917 WP_020946503.1 NZ_CP071777:c3828023-3827670 [Proteus mirabilis]
MASLDVYMNEYYMGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIE

Nucleotide

• Length: 354 bp

>T196917 NZ_CP095511:30497-30802 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT196917 WP_004249771.1 NZ_CP071777:c3828281-3828024 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT196917 NZ_CP095511:30277-30495 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: B4F0T9