Detailed information of TA system TA196915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3521906..3522605
• Replicon: chromosome
• Accession: NZ_CP071777
• Organism: Proteus mirabilis strain swupm2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: J3U93_RS16105
• Protein ID: WP_004249093.1
• Coordinates: 3521906..3522292 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: J3U93_RS16110
• Protein ID: WP_004246828.1
• Coordinates: 3522285..3522605 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3U93_RS16090 (J3U93_16060)	3517925..3518506	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
J3U93_RS16095 (J3U93_16065)	3518757..3519662	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
J3U93_RS16100 (J3U93_16070)	3519672..3521744	+	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
J3U93_RS16105 (J3U93_16075)	3521906..3522292	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J3U93_RS16110 (J3U93_16080)	3522285..3522605	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
J3U93_RS16115 (J3U93_16085)	3522654..3523088	-	435	WP_020946391.1	hypothetical protein	-
J3U93_RS16120 (J3U93_16090)	3523081..3523965	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
J3U93_RS16125 (J3U93_16095)	3524183..3525469	-	1287	WP_253343077.1	DUF3748 domain-containing protein	-
J3U93_RS16130 (J3U93_16100)	3525606..3526223	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
J3U93_RS16135 (J3U93_16105)	3526525..3527148	+	624	WP_004246821.1	guanylate kinase	-
J3U93_RS16140 (J3U93_16110)	3527203..3527478	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T196915 WP_004249093.1 NZ_CP071777:3521906-3522292 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T196915 NZ_CP095510:4705534-4705791 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT196915 WP_004246828.1 NZ_CP071777:3522285-3522605 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT196915 NZ_CP095510:4705803-4706348 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97