Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 13291..13892 Replicon chromosome
Accession NZ_CP071777
Organism Proteus mirabilis strain swupm2

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag J3U93_RS00060 Protein ID WP_004246497.1
Coordinates 13291..13674 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag J3U93_RS00065 Protein ID WP_004246496.1
Coordinates 13671..13892 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3U93_RS00035 (J3U93_00035) 8353..9841 - 1489 Protein_6 PLP-dependent aminotransferase family protein -
J3U93_RS00040 (J3U93_00040) 9970..10428 + 459 WP_017628716.1 GNAT family N-acetyltransferase -
J3U93_RS00045 (J3U93_00045) 10524..11261 - 738 WP_004249950.1 tetratricopeptide repeat protein -
J3U93_RS00050 (J3U93_00050) 11370..12269 + 900 WP_253343102.1 N-acetylmuramic acid 6-phosphate etherase -
J3U93_RS00055 (J3U93_00055) 12569..12883 - 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
J3U93_RS00060 (J3U93_00060) 13291..13674 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
J3U93_RS00065 (J3U93_00065) 13671..13892 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J3U93_RS00070 (J3U93_00070) 14137..15000 - 864 WP_004249947.1 YicC/YloC family endoribonuclease -
J3U93_RS00075 (J3U93_00075) 15127..15843 + 717 WP_004249946.1 ribonuclease PH -
J3U93_RS00080 (J3U93_00080) 15925..16569 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
J3U93_RS00085 (J3U93_00085) 16888..17493 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
J3U93_RS00090 (J3U93_00090) 17613..18071 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T196913 WP_004246497.1 NZ_CP071777:c13674-13291 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T196913 NZ_CP095510:4561584-4561736 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT196913 WP_004246496.1 NZ_CP071777:c13892-13671 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT196913 NZ_CP095510:c4561535-4561478 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References