Detailed information of TA system TA196912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3827700..3828311
• Replicon: chromosome
• Accession: NZ_CP071773
• Organism: Proteus mirabilis strain swupm1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: J3U92_RS17450
• Protein ID: WP_020946503.1
• Coordinates: 3827700..3828053 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: J3U92_RS17455
• Protein ID: WP_004249771.1
• Coordinates: 3828054..3828311 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3U92_RS17430 (J3U92_17410)	3822933..3823736	+	804	WP_004249775.1	energy transducer TonB	-
J3U92_RS17435 (J3U92_17415)	3823790..3825751	-	1962	WP_004249774.1	insecticidal delta-endotoxin Cry8Ea1 family protein	-
J3U92_RS17440 (J3U92_17420)	3825783..3826712	-	930	WP_004246518.1	metallophosphoesterase	-
J3U92_RS17445 (J3U92_17425)	3826897..3827361	-	465	WP_012368636.1	DUF1097 domain-containing protein	-
J3U92_RS17450 (J3U92_17430)	3827700..3828053	-	354	WP_020946503.1	HipA N-terminal domain-containing protein	Toxin
J3U92_RS17455 (J3U92_17435)	3828054..3828311	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
J3U92_RS17460 (J3U92_17440)	3828460..3829824	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
J3U92_RS17465 (J3U92_17445)	3829962..3831602	-	1641	WP_004246512.1	membrane protein insertase YidC	-
J3U92_RS17470 (J3U92_17450)	3831605..3831865	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
J3U92_RS17475 (J3U92_17455)	3831829..3832188	-	360	WP_004246510.1	ribonuclease P protein component	-
J3U92_RS17480 (J3U92_17460)	3832206..3832349	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13146.76 Da
• Isoelectric Point: 4.5238

>T196912 WP_020946503.1 NZ_CP071773:c3828053-3827700 [Proteus mirabilis]
MASLDVYMNEYYMGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIE

Nucleotide

• Length: 354 bp

>T196912 NZ_CP095510:c4263822-4263481 [Escherichia coli]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCTGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGATACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCGGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT196912 WP_004249771.1 NZ_CP071773:c3828311-3828054 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT196912 NZ_CP095510:c4263471-4263172 [Escherichia coli]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGTGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACTCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCGAATGGTAAGAGAATTGCATTTCAGATTTAA

Structures

Antitoxin

• AlphaFold DB: B4F0T9