Detailed information of TA system TA196910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3521936..3522635
• Replicon: chromosome
• Accession: NZ_CP071773
• Organism: Proteus mirabilis strain swupm1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: J3U92_RS16080
• Protein ID: WP_004249093.1
• Coordinates: 3521936..3522322 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: J3U92_RS16085
• Protein ID: WP_004246828.1
• Coordinates: 3522315..3522635 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3U92_RS16065 (J3U92_16040)	3517955..3518536	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
J3U92_RS16070 (J3U92_16045)	3518787..3519692	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
J3U92_RS16075 (J3U92_16050)	3519702..3521774	+	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
J3U92_RS16080 (J3U92_16055)	3521936..3522322	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J3U92_RS16085 (J3U92_16060)	3522315..3522635	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
J3U92_RS16090 (J3U92_16065)	3522684..3523118	-	435	WP_020946391.1	hypothetical protein	-
J3U92_RS16095 (J3U92_16070)	3523111..3523995	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
J3U92_RS16100 (J3U92_16075)	3524213..3525499	-	1287	WP_253343077.1	DUF3748 domain-containing protein	-
J3U92_RS16105 (J3U92_16080)	3525636..3526253	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
J3U92_RS16110 (J3U92_16085)	3526555..3527178	+	624	WP_004246821.1	guanylate kinase	-
J3U92_RS16115 (J3U92_16090)	3527233..3527508	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T196910 WP_004249093.1 NZ_CP071773:3521936-3522322 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T196910 NZ_CP095510:3585129-3585515 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT196910 WP_004246828.1 NZ_CP071773:3522315-3522635 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT196910 NZ_CP095510:3585505-3585834 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97